Results 41 to 50 of about 182,437 (357)

Widespread erosion on high plateaus during recent glaciations in Scandinavia [PDF]

, 2018
Glaciers create some of Earth’s steepest topography; yet, many areas that were repeatedly overridden by ice sheets in the last few million years include extensive plateaus.
Andersen, Jane L., Egholm, David L., Fabel, Derek, Jansen, John D., Knudsen, Mads F., Linge, Henriette, Nielsen, Søren B., Olsen, Jesper, Pedersen, Vivi K., Tikhomirov, Dmitry, Xu, Sheng   +10 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Origin and structure of Devensian depressions at Letton, Herefordshire [PDF]

, 2010
Groups of circular to oval enclosed depressions in soft sediments of Pleistocene age are relatively common in north-west Europe. These features are normally interpreted as being either glacial or periglacial in origin.
Astin, Timothy Robin, Griffiths, Geoffrey Hugh, Gurney, Stephen David   +2 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Three hundred eighty thousand year long stable isotope and faunal records from the Red Sea : influence of global sea level change on hydrography [PDF]

, 1996
Stable isotope and faunal records from the central Red Sea show high-amplitude oscillations for the past 380,000 years. Positive δ18O anomalies indicate periods of significant salt buildup during periods of lowered sea level when water mass exchange with
Ahuva Almogi-Labin, Almogi-Labin, Almogi-Labin, Almogi-Labin, Anati, Anderson, Assaf, Berger, Berggren, Bethoux, Bijma, Birgit Hiller, Bonnefille, Brachert, Bryden, Bryden, Chen, Christoph Hemleben, Clemens, Clemens, COHMAP Members, Craig, Deuser, Deuser, Dieter Meischner, Fairbanks, Gasse, Helmut Erlenkeuser, Herman, Imbrie, Ivanova, Jasper, Kutzbach, Kutzbach, Labeyrie, Lezine, Locke, Milliman, Morcos, Niitsuma, Pachur, Pachur, Prell, Prell, Prell, Rainer Zahn, Reiss, Risch, Rohling, Rossignol-Strick, Sirocko, Thunell, Yusuf, Zahn   +53 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Pleistocene geochronologies for fluvial sedimentary sequences: an archaeologist's perspective [PDF]

, 2005
Current models of Pleistocene fluvial system development and dynamics are assessed from the perspective of European Lower and Middle Palaeolithic stone tool assemblages recovered from fluvial secondary contexts. Fluvial activity is reviewed both in terms
Anklin, Antoine, Ashton, Bibus, Bridgland, Bridgland, Bridgland, Bridgland, Bridgland, Brown, Bryant, Büdel, Chambers, Clayton, Cleveringa, Collins, Conway, Gamble, Gibbard, Gibbard, Green, Green, Hosfield, Hosfield, Houben, Houben, Howard, Huisink, Johnsen, Kasse, Lewis, Lowe, Macklin, Macklin, Maddy, Maddy, Maizels, Mass, Meese, Meinke, Murray, Murray, Pastre, Petit, Prescott, Roberts, Roe, Rose, Rose, Schirmer, Schirmer, Shackleton, Stuiver, Sörgel, Toms, Toms, Tuffreau, Tuffreau, Van Andel, Van Balen, Van Huissteden, Van Huissteden, Vandenberghe, Vandenberghe, Vandenberghe, Vandenberghe, Vandenberghe, Watts, White, Wymer, Wymer, Zeuner   +71 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Diverse phenotypes of Late Glacial–Early Holocene downy birch (Betula pubescens Erh.) and the morphology of early Preboreal tree stands in southern Schleswig-Holstein [PDF]

Eiszeitalter und Gegenwart
The flexibility in growth of Betula pubescens is taken as example for possible erroneous imaginations of Late Glacial–Early Holocene living conditions.
S. Krüger
doaj   +1 more source