Results 41 to 50 of about 178,686 (262)

Pleistocene geochronologies for fluvial sedimentary sequences: an archaeologist's perspective [PDF]

, 2005
Current models of Pleistocene fluvial system development and dynamics are assessed from the perspective of European Lower and Middle Palaeolithic stone tool assemblages recovered from fluvial secondary contexts. Fluvial activity is reviewed both in terms
Anklin, Antoine, Ashton, Bibus, Bridgland, Bridgland, Bridgland, Bridgland, Bridgland, Brown, Bryant, Büdel, Chambers, Clayton, Cleveringa, Collins, Conway, Gamble, Gibbard, Gibbard, Green, Green, Hosfield, Hosfield, Houben, Houben, Howard, Huisink, Johnsen, Kasse, Lewis, Lowe, Macklin, Macklin, Maddy, Maddy, Maizels, Mass, Meese, Meinke, Murray, Murray, Pastre, Petit, Prescott, Roberts, Roe, Rose, Rose, Schirmer, Schirmer, Shackleton, Stuiver, Sörgel, Toms, Toms, Tuffreau, Tuffreau, Van Andel, Van Balen, Van Huissteden, Van Huissteden, Vandenberghe, Vandenberghe, Vandenberghe, Vandenberghe, Vandenberghe, Watts, White, Wymer, Wymer, Zeuner   +71 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Origin and structure of Devensian depressions at Letton, Herefordshire [PDF]

, 2010
Groups of circular to oval enclosed depressions in soft sediments of Pleistocene age are relatively common in north-west Europe. These features are normally interpreted as being either glacial or periglacial in origin.
Astin, Timothy Robin, Griffiths, Geoffrey Hugh, Gurney, Stephen David   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Glacial events in Carboniferous sequences from Paganzo and Río Blanco Basins (Northwest Argentina): Palynology and depositional setting [PDF]

, 2010
The age and depositional setting of two glacial events recognized in the western basins of Argentina are discussed in this paper. The older one corresponds to diamictites identified in the upper member of the Cortaderas Formation (Visean, Río Blanco ...
Césari, S.N., Limarino, C.O., Pérez Loinaze, V.S.   +2 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Geochemical constraints on the origin of enigmatic cemented chalks, Norfolk, UK [PDF]

, 2009
Very hard cemented chalk stacks and crusts found locally in the upper part of the Cretaceous Chalk of north Norfolk, UK, are related to solution features.
A. MARCA-BELL, G. WOOLHOUSE, Hiscock, J. E. ANDREWS, Johansen, Lee, McArthur, Mortimore, P. F. DENNIS, Peake, Peake, Pitchford, Scholle, Thurston   +13 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Astronomical forcing shaped the timing of early Pleistocene glacial cycles

Communications Earth & Environment, 2023
Glacial cycles during the early Pleistocene are characterised by a dominant 41,000-year periodicity and amplitudes smaller than those of glacial cycles with ~100,000-year periodicity during the late Pleistocene. However, it remains unclear how the 41,000-
Yasuto Watanabe, Ayako Abe-Ouchi, Fuyuki Saito, Kanon Kino, Ryouta O’ishi, Takashi Ito, Kenji Kawamura, Wing-Le Chan   +7 more
doaj   +1 more source