Results 51 to 60 of about 180,240 (308)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Astronomical forcing shaped the timing of early Pleistocene glacial cycles
Communications Earth & Environment, 2023 Glacial cycles during the early Pleistocene are characterised by a dominant 41,000-year periodicity and amplitudes smaller than those of glacial cycles with ~100,000-year periodicity during the late Pleistocene. However, it remains unclear how the 41,000-
Yasuto Watanabe +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Diverse phenotypes of Late Glacial–Early Holocene downy birch (Betula pubescens Erh.) and the morphology of early Preboreal tree stands in southern Schleswig-Holstein [PDF]
Eiszeitalter und GegenwartThe flexibility in growth of Betula pubescens is taken as example for possible erroneous imaginations of Late Glacial–Early Holocene living conditions.
S. Krüger
doaj +1 more source
A geomorphological overview of glacial landforms on the Icelandic continental shelf [PDF]
, 2009 The availability of a bathymetric database that covers about 80% of the Icelandic shelf has made it possible to produce a geomorphological map of the glacial landforms.
Clark, C.D., Spagnolo, M.
core +1 more source
Obliquity pacing of the late Pleistocene glacial terminations [PDF]
Nature, 2005 The 100,000-year timescale in the glacial/interglacial cycles of the late Pleistocene epoch (the past approximately 700,000 years) is commonly attributed to control by variations in the Earth's orbit. This hypothesis has inspired models that depend on the Earth's obliquity (approximately 40,000 yr; approximately 40 kyr), orbital eccentricity ...
Huybers, Peter, Wunsch, Carl
openaire +3 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Palaeoenvironment of a mesolithic peat bed from Austin Friars, Leicester [PDF]
, 1984 A mesolithic peat bed, dated to 9920±100 bp (HAR-4260) (bp = radiocarbon years before the present calculated from A.D. 19S0 within + or - of 100 years in this case. Ed.) was recovered from Austin Friars, Leicester.
Hunt, SA, Shackley, M
core
Late Glacial Landscape Ecology in Central North America [PDF]
, 2007 The transition from full glacial to interglacial conditions along the southern margin of the Laurentide ice sheet resulted in dramatic changes in landscapes and biotic habitats.
Hill, Christopher L.
core +2 more sources