Results 71 to 80 of about 180,240 (308)

Sea surface temperature changes in the southern California borderlands during the last glacial-interglacial cycle [PDF]

, 1996
A variety of evidence suggests that average sea surface temperatures (SSTs) during the last glacial maximum in the California Borderlands region were significantly colder than during the Holocene.
Bandy, Bard, Berelson, Berger, Bond, Bond, Bradshaw, Clark, CLIMAP Project Members, Climate: Long-Range Investigation, Cooperative Holocene Mapping Project (COHMAP) Members, Coulbourn, Dansgaard, David M. Anderson, Epstein, Fairbanks, Fairbanks, Fischer, Gorsline, Gorsline, Grootes, Hickey, Hickey, Hickey, Hutson, Huyer, Imbrie, Imbrie, Jahnke, Jianning Le, Kahn, Kennett, Kennett, Kheradpir, Lowell D. Stott, Martin, Martin, Martinson, McIntyre, Okada, Overpeck, P. Graham Mortyn, Prahl, Prell, Reynolds, Robert C. Thunell, Sautter, Sautter, Taylor, Thunell, Thunell, Thunell, Tont   +52 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Middle and Late Pleistocene environmental history of the Marsworth area, south-central England [PDF]

, 2014
To elucidate the Middle and Late Pleistocene environmental history of south-central England, we report the stratigraphy, sedimentology, palaeoecology and geochronology of some deposits near the foot of the Chiltern Hills scarp at Marsworth ...
Adamiec, Andrew Currant, Andrews, Avery, Ballantyne, Barrow, Bascomb, Bates, Bates, Bates, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bowen, Bridgland, Candy, Candy, Candy, Canti, Christopher P. Green, Clark, Clayden, Coope, Coope, Currant, Danielle C. Schreve, David H. Keen, David Parish, David Q. Bowen, de Deckker, de Rouffignac, EPICA community members, Evans, Evans, Evans, Galbraith, Gibbard, Gibbard, Gibbard, Gibbard, Green, Green, Gregory, Griffiths, Hamblin, Harmer, Harris, Hill, Hiltermann, Holyoak, Horton, Huntley, Ian Candy, Jarvis, John A. Catt, John G. Evans, Jones, Jones, Jouzel, Julian B. Murton, Kandiano, Kaufman, Keen, Keen, Keen, Keen, Keen, Kerney, Kerney, Kirsty Penkman, Linda L. York, Lisiecki, Lister, Lister, Loveday, Maddy, Markey, McManus, Meijer, Meisch, Mejdahl, Michael P. Kerney, Michael R. Frogley, Miller, Miller, Morgan, Mortimore, Murray, Murray, Murray, Murton, Murton, Murton, Murton, Murton, Murton, Oakley, Oches, Pawley, Penkman, Penkman, Penkman, Penkman, Penkman, Peter Worsley, Phillip S. Toms, Preece, Preece, Prescott, Robinson, Rose, Rousseau, Schreve, Sheila Taylor, Shephard-Thorn, Shephard-Thorn, Sherlock, Sherlock, Soil Survey of England and Wales, Sparks, Stathoplos, Straw, Sumbler, Sumbler, Sykes, Wehmiller, Wenban-Smith, Whiteman, Williams, Williams, Williams, Worsley, Zimmerman   +137 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The deglaciation of the mountains of Mexico and Central America

Cuadernos de Investigación Geográfica, 2017
The last deglaciation is an interval of marked changes in the climate system. The records of glaciation of tropical mountains offer unique opportunities to assess the timing of changes and the sensitivity of tropical climates to global and regional ...
L. Vázquez-Selem, M.S. Lachniet
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Paleoenvironment conditions of the bottom sediment formation in the small lake depressions on the Pomorsky coast of the White Sea

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015
New lithological, palinological and chronological data obtained through the study of bottom sediments from four small lake depressions on the Pomor Coast, Onega Bay, White Sea are presented.
Vasili Kolka, Olga Korsakova, Nadezhda Lavrova   +2 more
doaj   +1 more source

The last glacial-interglacial cycle in Lake Ohrid (Macedonia/Albania): testing diatom response to climate [PDF]

, 2010
Lake Ohrid is a site of global importance for palaeoclimate research. This study presents results of diatom analysis of a ca. 136 ka sequence, Co1202, from the northeast of the lake basin.
Cvetkoska, A., Levkov, Z., Reed, J. M., Vogel, H., Wagner, B.   +4 more
core   +5 more sources

The Late‐glacial reoccupation of the British Isles and the Creswellian

Journal of Quaternary Science, 2003
AbstractThis paper presents a review of AMS radiocarbon dating evidence for human occupation of Britain during the Late‐glacial Interstadial. The dates are all on humanly modified materials, including artefacts, and on human bone. The CalPal program is used to test whether the earliest evidence of human presence shows any correlation with more ...
Barton, R, Jacobi, R, Stapert, D, Street, M   +3 more
openaire   +1 more source