Results 81 to 90 of about 180,240 (308)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Les Nouvelles de l’Archéologie, 2015 This collective project of research, which started in 2009, is dedicated to hunter-gatherers societies in Paris Basin from the fourteenth millenium cal BC until the sixth millenium cal BC, i.e during the Late Glacial and the beginning of the Post Glacial.
Boris Valentin
doaj +1 more source
Reconciling diverse lacustrine and terrestrial system response to penultimate deglacial warming in southern Europe [PDF]
, 2015 Unlike the most recent deglaciation, the regional expression of climate changes during the penultimate deglaciation remains understudied, even though it led into a period of excess warmth with estimates of global average temperature 1–2 °C, and sea level
Frogley, Michael R +4 more
core +3 more sources
Late Quaternary glacial phases in the Iberian Peninsula
Earth-Science Reviews, 2019 The only glaciers existing today in the Iberian Peninsula are small features located in the Pyrenees, though their number and extension has undergone significant changes over the Late Quaternary. The wide range of glacial landforms and deposits distributed across different Iberian ranges suggests the occurrence of several past periods with larger ...
Oliva, M. +10 more
openaire +8 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The northern sector of the last British ice sheet : maximum extent and demise [PDF]
, 2008 Strongly divided opinion has led to competing, apparently contradictory, views on the timing, extent, flow configuration and decay mechanism of the last British Ice Sheet.
Bradwell, Tom +11 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Palaeoenvironmental record of the last 70 000 yr in San Felipe Basin, Sonora desert, Mexico: preliminary results [PDF]
Geofísica Internacional, 1999 Preliminary results of a palaeoenvironmental research which includes particle size analyses, diatom and rock-magnetic analyses for a 9.5 m long core from Laguna Seca de San Felipe (LSSF), Baja California, are presented.
De la O Villanueva, Margarita +3 more
doaj
A persistent and dynamic East Greenland Ice Sheet over the past 7.5 million years [PDF]
, 2016 Climate models show that ice-sheet melt will dominate sea-level rise over the coming centuries, but our understanding of ice-sheet variations before the last interglacial 125,000 years ago remains fragmentary.
Bierman, Paul R. +4 more
core +2 more sources