Results 61 to 70 of about 38,197 (265)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Planktonic foraminiferal Mg/Ca as a proxy for past oceanic temperatures: a methodological overview and data compilation for the Last Glacial Maximum [PDF]

, 2005
As part of the Multi-proxy Approach for the Reconstruction of the Glacial Ocean (MARGO) incentive, published and unpublished temperature reconstructions for the Last Glacial Maximum (LGM) based on planktonic foraminiferal Mg/Ca ratios have been ...
Tachikawa, Kazuyo, Barker, S., Benway, H., Cacho, I., Barker, Stephen, Barker, S, Benway, Heather, Cacho, I, Cacho, Isabel, Tachikawa, K., Kazuyo, Tachikawa, Benway, H, Tachikawa, K   +12 more
core   +1 more source

Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. [PDF]

Nat Ecol Evol, 2022
Charlton S, Brace S, Hajdinjak M, Kearney R, Booth T, Reade H, Tripp JA, Sayle KL, Grimm SB, Bello SM, Walker EA, Gilardet A, East P, Glocke I, Larson G, Higham T, Stringer C, Skoglund P, Barnes I, Stevens RE.   +19 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Enhanced chemical weathering of rocks during the last glacial maximum: a sink for atmospheric CO2? [PDF]

, 1999
It has been proposed that increased rates of chemical weathering and the related drawdown of atmospheric CO2 on the continents may have at least partly contributed to the low CO2 concentrations during the last glacial maximum LGM..
Probst, Jean-Luc, Amiotte Suchet, Philippe, Ludwig, Wolfgang, Philippe Amiotte-Suchet, Jean-Luc Probst, Wolfgang Ludwig   +5 more
core   +1 more source

Summer paleohydrology during the Late Glacial and Early Holocene based on δ²H and δ¹⁸O from Bichlersee, Bavaria. [PDF]

Sci Rep, 2023
Prochnow M, Strobel P, Bliedtner M, Struck J, Bittner L, Szidat S, Salazar G, Schneider H, Acharya S, Zech M, Zech R.   +10 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

A Continuous Centennial Late Glacial-Early Holocene (15-10 cal kyr BP) Palynological Record from the Iberian Pyrenees and Regional Comparisons. [PDF]

Plants (Basel), 2023
Rull V, Blasco A, Calero MÁ, Blaauw M, Vegas-Vilarrúbia T.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Vegetation and environmental dynamics in the Páramo of Jimbura region in the southeastern Ecuadorian Andes during the late Quaternary.

, 2012
The last 15,000 years of vegetation, fire and climate history were reconstructed from the Laguna Natosa Peat bog core (3600 m elevation) in the Páramo of Jimbura region in the Cordillera Real, close to the Peruvian border of southern Ecuador in the ...
León Yánez, Susana Del Consuelo
core   +1 more source