Results 51 to 60 of about 182,437 (357)

Astronomical forcing shaped the timing of early Pleistocene glacial cycles

Communications Earth & Environment, 2023
Glacial cycles during the early Pleistocene are characterised by a dominant 41,000-year periodicity and amplitudes smaller than those of glacial cycles with ~100,000-year periodicity during the late Pleistocene. However, it remains unclear how the 41,000-
Yasuto Watanabe, Ayako Abe-Ouchi, Fuyuki Saito, Kanon Kino, Ryouta O’ishi, Takashi Ito, Kenji Kawamura, Wing-Le Chan   +7 more
doaj   +1 more source

Northern Hemisphere Glaciation during the Globally Warm Early Late Pliocene [PDF]

, 2013
The early Late Pliocene (3.6 to ~3.0 million years ago) is the last extended interval in Earth's history when atmospheric CO2 concentrations were comparable to today's and global climate was warmer.
DeSchepper, Stijn, Groeneveld, J, Head, M, Hennissen, Jan, Karl, Fabian, Louwye, Stephen, Naafs, B D A, Renterghem, Cédéric   +7 more
core   +6 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Palaeoenvironment of a mesolithic peat bed from Austin Friars, Leicester [PDF]

, 1984
A mesolithic peat bed, dated to 9920±100 bp (HAR-4260) (bp = radiocarbon years before the present calculated from A.D. 19S0 within + or - of 100 years in this case. Ed.) was recovered from Austin Friars, Leicester.
Hunt, SA, Shackley, M
core  

Syngenetic sand veins and anti-syngenetic sand wedges, Tuktoyaktuk Coastlands, western Arctic Canada [PDF]

, 2007
Sand-sheet deposits of full-glacial age in the Tuktoyaktuk Coastlands, western Arctic Canada, contain syngenetic sand veins 1-21 cm wide and sometimes exceeding 9 m in height.
Bateman, Bateman, Berg, Brookfield, Burn, Carter, Carter, Dallimore, Dinter, Dostovalov, Dylik, Environment Canada, French, French, Ghysels, Gozdzik, Harry, Hopkins, Julian B. Murton, Kasper, Kasse, Kocurek, Kolstrup, Kolstrup, Kolstrup, Kolstrup, Koster, Koster, Koster, Lea, Lea, Lea, Lewkowicz, MacDonald, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mark D. Bateman, Melnikov, Murton, Murton, Murton, Péwé, Rampton, Ritchie, Sher, Sletten, Taylor, Van der Hammen, Vandenberghe, Vasil'chuk, Worsley, Yershov   +57 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Effects of Pleistocene climate changes on species ranges and evolutionary processes in the Neotropical Atlantic Forest [PDF]

, 2016
The effects of global glaciations on the distribution of organisms is an essential element of many diversification models. However, the empirical evidence supporting this idea is mixed, in particular with respect to explaining tropical forest evolution ...
Cabanne, Gustavo Sebastián, Calderón, Pablo Luciano Sebastian, d'Horta, Fernando M., Flores, Pamela, Miyaki, Cristina Y., Pessoa, Rodrigo, Trujillo Arias, Natalia   +6 more
core   +2 more sources

A Late Glacial family at Trollesgave, Denmark

Journal of Archaeological Science, 2015
AbstractMicrowear analysis is applied to reconstruct the function and social organisation at the Late Glacial site of Trollesgave, Denmark. As with Bromme Culture sites in general, the lithic assemblage consists of primarily three types of tools. There is a strong association between these types and their use: end scrapers for dry hide scraping; burins
Donahue, Randolph E., Fischer, Anders
openaire   +2 more sources