FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Frontiers in Earth ScienceIdentifying the late Holocene Indian summer monsoon (ISM) changes and their possible forcing mechanisms provides an important perspective for understanding the current monsoon shifts driven by anthropogenic climate change within a natural baseline.
Dongliang Ning +4 more
doaj +1 more source
Late Pleistocene to Holocene event stratigraphy of Lake Hallstatt (Salzkammergut, Austria): revealed by the Hipercorig drilling system and borehole logging [PDF]
Scientific DrillingThe Hipercorig Hallstatt History (H3) project aims to unravel the entire Late Glacial to Holocene sedimentary succession recording past climate, environment, natural hazard impacts, human–environment interactions, and prehistoric mining history.
M. Ortler +11 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Diverse phenotypes of Late Glacial–Early Holocene downy birch (Betula pubescens Erh.) and the morphology of early Preboreal tree stands in southern Schleswig-Holstein [PDF]
Eiszeitalter und GegenwartThe flexibility in growth of Betula pubescens is taken as example for possible erroneous imaginations of Late Glacial–Early Holocene living conditions.
S. Krüger
doaj +1 more source
Lake Diatoms as a Proxy for Holocene Environmental Change, West Greenland [PDF]
, 2013 There is great interest over the Greenland Ice Sheet in terms of future climate change, though there is a lack of understanding of climate change during the Holocene.
BEST, LOUISE,ALICE
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Holocene mangrove dynamics and sea level changes: records from the Tanzanian coast [PDF]
, 2013 Tanzanian mangrove ecosystems have been, and are presently, influenced by changes in climate and sea level. Fluctuations in these environmental conditions lead to adaptations and changes in ecosystem structure and composition.
Punwong, Paramita
core +2 more sources
Stratigraphy and palaeoenvironment of the Bangkok Clay (Holocene) from Samut Sakhon Province, Central Thailand [PDF]
Journal of MicropalaeontologyThis study investigates the lithostratigraphy and palaeoenvironmental conditions of Holocene sediments from five boreholes in the Lower Central Plain of Thailand, with a focus on ostracod assemblages and sedimentary facies.
L. Weerachai +4 more
doaj +1 more source