Results 81 to 90 of about 1,274,726 (282)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses.

PLoS Pathogens, 2020
The induction of an interferon-mediated response is the first line of defense against pathogens such as viruses. Yet, the dynamics and extent of interferon alpha (IFNα)-induced antiviral genes vary remarkably and comprise three expression clusters: early,
Katharina Robichon, Tim Maiwald, Marcel Schilling, Annette Schneider, Joschka Willemsen, Florian Salopiata, Melissa Teusel, Clemens Kreutz, Christian Ehlting, Jun Huang, Sajib Chakraborty, Xiaoyun Huang, Georg Damm, Daniel Seehofer, Philipp A Lang, Johannes G Bode, Marco Binder, Ralf Bartenschlager, Jens Timmer, Ursula Klingmüller   +19 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

On field theory quantization around instantons

, 1995
With the perspective of looking for experimentally detectable physical applications of the so-called topological embedding, a procedure recently proposed by the author for quantizing a field theory around a non-discrete space of classical minima ...
't Hooft G, Anselmi D, Anselmi D, Belavin A A, Coleman S, Damiano Anselmi, De Gennes P G, Faddeev L D, Garcia-Prada O, Kontsevich M, Rajaraman R, Samols T M, Strebel K, Taubes C H, Taubes C H, Tinkham M   +15 more
core   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

MYRACRODRUON URUNDEUVA FR ALL. (AROEIRA TREE) POPULATION DYNAMICS, DIAMETER GROWTH RATE AND ITS POTENTIAL FOR SUSTAINABLE MANAGEMENT IN SUCCESSIONAL TROPICAL DRY FORESTS OF BRAZIL

Revista Árvore, 2018
Myracrodruon urundeuva, better known in Brazil as “Aroeira”, is an arboreal species highly used for its commercial and pharmacological value. Despite the high commercial value in the timber market, this species lacks studies analyzing the recovery time ...
Sofia Calvo Rodriguez, Julio Calvo Alvarado, Mario Marcos do Espírito-Santo, Yule Roberta Ferreira Nunes   +3 more
doaj   +1 more source

Testing the companion hypothesis for the origin of the X-ray emission from intermediate-mass main-sequence stars

, 2006
There is no straightforward explanation for intrinsic X-ray emission from intermediate-mass main-sequence stars. Therefore the observed emission is often interpreted in terms of (hypothesized) late-type magnetically active companion stars. We use Chandra
Abt, Andersen, B. Stelzer, Babel, Babel, Baraffe, Berghöfer, Berghöfer, Bychkov, Caillault, Cash, Catanzaro, Close, Daniel, de Geus, de Zeeuw, Dodd, Duquennoy, Eggen, Feigelson, Freeman, Frost, G. Micela, Gahm, Gehrels, Gerbaldi, Getman, Hogg, Hubrig, Huélamo, Huélamo, Hünsch, Isobe, Kenyon, Kouwenhoven, Kraft, Landstreet, Lindroos, Lindroos, Lindroos, Lucy, N. Huélamo, Owocki, Palla, Pallavicini, Parker, Parker, Patten, Preibisch, Preibisch, Raymond, Renson, Royer, Ryter, Rüdiger, S. Hubrig, Schmitt, Schmitt, Schmitt, Schneider, Shatsky, Smith, Stelzer, Stelzer, Stelzer, Stelzer, Wilms, Wolk, Yushchenko   +68 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source