Results 141 to 150 of about 1,127,406 (357)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Migration in European History since the Late Middle Ages.

, 2018
Klaus J. Bade
openalex   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Man and Natural Disaster in the Late Middle Ages: The Earthquake in Carinthia and Northern Italy on 25 January 1348 and its Perception

, 2003
C. Rohr
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Technological innovations and hafted technology in central China ~160,000-72,000 years ago. [PDF]

Nat Commun
Yue JP, Song GD, Yang SX, Kang SG, Li JY, Marwick B, Ollé A, Fernández-Marchena JL, Shu PX, Liu HY, Zhang YX, Huan FX, Zhao QP, Qiao BT, Shen ZS, Deng CL, Petraglia M.   +16 more
europepmc   +1 more source

Ideas of Power in the Late Middle Ages, 1296-1417

, 2011
J. Canning
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Reconstructing Eocene Antarctic river drainage from provenance analysis of Amundsen Sea embayment sediments. [PDF]

Sci Adv
Marschalek JW, van de Flierdt T, Siddoway CS, Thomson SN, Paxman GJG, Jamieson SSR, Conrad E, Licht KJ, Hemming SR, Bentley MJ, Hillenbrand CD, Smith JA, Klages JP, Fox M, Pastore G, Vermeesch P.   +15 more
europepmc   +1 more source

Physical Activity and Changes in Health Care Costs in Late Middle Age [PDF]

, 2006
Tatiana Andreyeva, Roland Sturm
openalex   +1 more source