Results 141 to 150 of about 4,144,511 (302)
English Mysticism in the Late Middle Ages [PDF]
, 2007 This work can be divided to the two main themes which the first one has a function of introduction this for Central Europe a little exotic theme. First chapters treat of History of England in the Late Middle Ages. I want to present this historical period.
Kotrlý, Karel
core
Historia. Instituciones. Documentos, 2009 The purpose of this article is to review the historiography of anti-seigneurial conflict during the Late Middle Ages in Castile. The study of social conflict and especially antiseigneurial conflict was one of the main interests of study of the late ...
Hipólito Rafael Oliva Herrer
doaj
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Artistic patronage in late medieval Troyes, 1380-1520 [PDF]
, 2013 This thesis explores the development of artistic patronage in the city of Troyes between 1380 and 1520. It takes into consideration the patrons and artists involved in the creation of manuscript illumination, sculpture, metalwork, panel painting ...
Wyant, Cody James
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Postan, Population, and Prices in Late-Medieval England and Flanders [PDF]
This paper re-examines the classic demographic or 'real' model, essentially based on a Malthusian-Ricardian model, that the late Michael Postan (Cambridge) utilized to explain the behaviour of the later-medieval western European economy, and in ...
John Munro
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source