Results 151 to 160 of about 178,775 (272)

Spiral Tube Decorations: a Thousand Years of Tradition

open access: yesEXARC Journal, 2016
An overview of finds, their regional spread and significance though the ages. The spiral tubes are made of an alloy that consists of copper supplemented mainly with zinc and/or tin (Rammo, Ratas 2015, table 1).
Riina Rammo, Jaana ratas
doaj  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Conflictos antiseñoriales en el reino de Castilla a fines de la Edad Media:viejas preguntas, ¿Nuevas respuestas?

open access: yesHistoria. Instituciones. Documentos, 2009
The purpose of this article is to review the historiography of anti-seigneurial conflict during the Late Middle Ages in Castile. The study of social conflict and especially antiseigneurial conflict was one of the main interests of study of the late ...
Hipólito Rafael Oliva Herrer
doaj  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

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