Results 171 to 180 of about 4,144,511 (302)

Genetic Risk, Lifestyle, and Colorectal Cancer Across Age at Onset: A Prospective UK Biobank Study. [PDF]

Cancer Med
Sun W, Liu D, Liu J, Wang D, Wang X, Zheng D, Ji J.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A survey of European astronomical tables in the late middle ages

, 2012
This is a survey of the numerous astronomical tables compiled in the late Middle Ages, which represent a major intellectual enterprise. Such tables were often the best way available at the time for transmitting precise information to the ...
Goldstein, Bernard R, Chabás, José
core  

Palaeoproteomic and genetic insights into millennial-scale dairy consumption in Armenia. [PDF]

iScience
Antonosyan M, Hovhannisyan A, Roberts P, Cassidy LM, Mkrtchyan S, Simonyan H, Bobokhyan A, Aghikyan L, Piliposyan A, Badalyan R, Yeranyan N, Gnuni A, Avetisyan H, Badalyan M, Gabrielyan A, Sarkisian N, Grigoryan A, Simonyan H, Safaryan M, Vardanyan B, Martirosyan-Olshansky K, Jackson I, Breslin E, Gyonjyan A, Khachatryan Z, Ilgner J, Yepiskoposyan L, Manica A, Bradley DG, Boivin N, Wilkin S.   +30 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Unique features of peer relationships in specific developmental periods predict borderline personality disorder and major depressive disorder in late adolescence. [PDF]

BMC Psychiatry
Naeem S, Gilbert K, Vogel AC, Huntington C, Tillman R, Barch DM, Luby J, Whalen DJ.   +7 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Tectono-paleogeographic evolution of the Northern Margin of the North China Block based on provenance analysis of Jurassic strata in Liaodong Peninsula. [PDF]

Sci Rep
Xu J, Gao B, Pu C.
europepmc   +1 more source

The Heresy in the Late Middle Ages

Abstract The history of the heresy of the Free Spirit and the medieval construction of a Free Spirit sect is tightly interwoven with the concept of heretical Beghards and cannot be understood in isolation from the history of late medieval lay religiosity, and the lay religious communities of Beguines (and, to a far lesser degree ...
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source