Results 51 to 60 of about 54,552 (242)

Measuring the performance of LPA, LCGA, LGCM, and GMM in identifying the homogenous subgroups (latent classes) within the wider heterogeneous population of patients on DTG

Frontiers in Applied Mathematics and Statistics
BackgroundIdentifying heterogeneity in longitudinal data is critical for understanding diverse trajectories in clinical and epidemiological research. Traditional analytical methods often fail to distinguish latent subpopulations.
Harrid Nkhoma, Atupele Ngina Mulaga, Save Kumwenda, Mphatso Kamndaya   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Recovery Trajectories of Executive Functioning After Pediatric TBI: A Latent Class Growth Modeling Analysis [PDF]

Journal of Head Trauma Rehabilitation, 2017
Objective: To identify latent trajectories of executive functioning (EF) recovery overtime after childhood traumatic brain injury (TBI) and examine the predictive value of known risk factors within and across recovery trajectories using latent class growth modeling (LCGM). Method: A
Megan E, Narad, Amery, Treble-Barna, James, Peugh, Keith O, Yeates, H Gerry, Taylor, Terry, Stancin, Shari L, Wade   +6 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Time course of neck-shoulder pain among workers: A longitudinal latent class growth analysis

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: The aims of this study were to (i) identify trajectories of neck-shoulder pain (NSP) over one year in an occupational population and (ii) determine whether these trajectories are predicted by NSP characteristics as well as personal and ...
David M Hallman, Charlotte Diana Nørregaard Rasmussen, Marie Birk Jørgensen, Andreas Holtermann   +3 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Adolescent determinants of life-course leisure-time vigorous physical activity trajectories: a 27-Year longitudinal study

BMC Public Health, 2023
Background Adolescence is regarded as formative years for building the foundations for life-long health and well-being, and adolescent determinants of physical activity (PA) development is particularly interesting.
Frida Kathrine Sofie Mathisen, Sara Madeleine Kristensen, Coral Falco, Bente Wold   +3 more
doaj   +1 more source

Family income trajectory during childhood is associated with adiposity in adolescence: a latent class growth analysis [PDF]

BMC Public Health, 2012
Childhood socioeconomic disadvantage has been linked with obesity in cross-sectional research, although less is known about how changes in socioeconomic status influence the development of obesity. Researchers have hypothesized that upward socioeconomic mobility may attenuate the health effects of earlier socioeconomic disadvantage; while downward ...
Kendzor Darla E, Caughy Margaret O, Owen Margaret   +2 more
openaire   +3 more sources