Results 61 to 70 of about 56,663 (274)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Measuring the performance of LPA, LCGA, LGCM, and GMM in identifying the homogenous subgroups (latent classes) within the wider heterogeneous population of patients on DTG

Frontiers in Applied Mathematics and Statistics
BackgroundIdentifying heterogeneity in longitudinal data is critical for understanding diverse trajectories in clinical and epidemiological research. Traditional analytical methods often fail to distinguish latent subpopulations.
Harrid Nkhoma, Atupele Ngina Mulaga, Save Kumwenda, Mphatso Kamndaya   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Recovery Trajectories of Executive Functioning After Pediatric TBI: A Latent Class Growth Modeling Analysis [PDF]

Journal of Head Trauma Rehabilitation, 2017
Objective: To identify latent trajectories of executive functioning (EF) recovery overtime after childhood traumatic brain injury (TBI) and examine the predictive value of known risk factors within and across recovery trajectories using latent class growth modeling (LCGM). Method: A
Megan E, Narad, Amery, Treble-Barna, James, Peugh, Keith O, Yeates, H Gerry, Taylor, Terry, Stancin, Shari L, Wade   +6 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Time course of neck-shoulder pain among workers: A longitudinal latent class growth analysis

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: The aims of this study were to (i) identify trajectories of neck-shoulder pain (NSP) over one year in an occupational population and (ii) determine whether these trajectories are predicted by NSP characteristics as well as personal and ...
David M Hallman, Charlotte Diana Nørregaard Rasmussen, Marie Birk Jørgensen, Andreas Holtermann   +3 more
doaj   +1 more source

Using latent class growth analysis to identify childhood wheeze phenotypes in an urban birth cohort [PDF]

Annals of Allergy, Asthma & Immunology, 2012
To advance asthma cohort research, we need a method that can use longitudinal data, including when collected at irregular intervals, to model multiple phenotypes of wheeze and identify both time-invariant (eg, sex) and time-varying (eg, environmental exposure) risk factors.To demonstrate the use of latent class growth analysis (LCGA) in defining ...
Qixuan, Chen, Allan C, Just, Rachel L, Miller, Matthew S, Perzanowski, Inge F, Goldstein, Frederica P, Perera, Robin M, Whyatt   +6 more
openaire   +2 more sources

Latent class growth analysis procedure and model fit.

, 2019
Latent class growth analysis procedure and model fit.
Jaap van Weeghel (532144), Astrid Kamperman (4533631), Hans Kortrijk (6190970), Barbara Schaefer (6190973), Cornelis L. Mulder (532148)   +4 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Trajectories of Body Dissatisfaction and Dietary Restriction in Early Adolescent Girls: A Latent Class Growth Analysis [PDF]

Journal of Youth and Adolescence, 2015
© 2015, Springer Science+Business Media New York. Clarifying the trajectories of body image and eating concerns in adolescents is critical. We examined longitudinal patterns of development of body dissatisfaction and dietary restriction among early adolescent girls within a sociocultural framework. A sample of 259 school girls (Mage = 12.76 years, SD =
Rodgers, RF, McLean, Sian, Marques, M, Dunstan, CJ, Paxton, Susan J   +4 more
openaire   +3 more sources