Results 41 to 50 of about 9,854,297 (301)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Relative influence of genetics and shared environment on child mental health symptoms depends on comorbidity. [PDF]

PLoS ONE, 2014
Comorbidity among childhood mental health symptoms is common in clinical and community samples and should be accounted for when investigating etiology.
Matthew K Vendlinski, Kristin N Javaras, Carol A Van Hulle, Kathryn Lemery-Chalfant, Rose Maier, Richard J Davidson, H Hill Goldsmith   +6 more
doaj   +1 more source

Estimating multiple classification latent class models

, 1999
latent class models, latent response models, cognitive processes, EM-algorithm,
Maris, E.G.G., E. Maris
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Trajectory of early creatinine change is associated with the prognosis of sepsis patients

BMC Infectious Diseases
Background Numerous studies have investigated the creatinine in patients with sepsis, and many meaningful results have been obtained. However, few studies have measured the creatinine multiple times and established trajectory models for patients with ...
Dan Liu, Zhonglin Zhang, Aihua Qin, Xiaofeng Li, Jian Zhao, Huihua Jiang, Yi Zhao, Yuanzhuo Chen, Hu Peng   +8 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Classification of Student Leadership Profiles in Diverse Governance Settings: Insights from Pisa 2022

Behavioral Sciences
Student leadership prepares students for responsibilities, such as taking on specific tasks and assuming leadership roles in their future personal and professional lives.
Deniz Görgülü, Fatma Coşkun, Mete Sipahioğlu, Mustafa Demir   +3 more
doaj   +1 more source

DeepCLSMOTE: deep class-latent synthetic minority oversampling technique [PDF]

PeerJ Computer Science
Deep learning models often exhibit bias when trained on imbalanced datasets, tending to favor majority classes. While Deep Synthetic Minority Over-sampling Technique (DeepSMOTE) mitigates this challenge by generating synthetic minority class images ...
Suvaporn Homjandee, Krung Sinapiromsaran
doaj   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source