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A Primer to Latent Profile and Latent Class Analysis

, 2021
This chapter gives an applied introduction to latent profile and latent class analysis (LPA/LCA). LPA/LCA are model-based methods for clustering individuals in unobserved groups. Their primary goals are probing whether and, if so, how many latent classes can be identified in the data, and to estimate the proportional size and response profiles of these
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Maternal postpartum depression literacy subtypes: A latent profile analysis

Heliyon, 2023
Aim: To explore the potential categories and characteristic differences of maternal postpartum depression literacy. Design: Cross-sectional survey. Methods: From February 2023 to April 2023, convenience sampling was used to survey 278 women attending ...
Kangfen Li, Jie Lu, Yan Pang, Xinlie Zheng, Ran Liu, Min Ren, Suhua Tu   +6 more
doaj   +1 more source

Participation profiles among Chinese stroke survivors: A latent profile analysis

PLOS ONE, 2020
Objectives To investigate the current status of participation and explore the characteristics of individuals with different levels of participation among stroke survivors in mainland China. Design Cross-sectional survey. Setting Participants were recruited by convenience sampling from the neurology department of the tertiary hospitals and ...
Yuxia Li, Xuemei Li, Lanshu Zhou
openaire   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Personality profile analysis, personality-intelligence profile analysis, and the intergenerational transmission of both: Insights from Chinese evidence

Acta Psychologica
An individual-centered latent personality profile analysis represents a novel approach to personality research. Leveraging the China Family Panel Studies (CFPS) dataset, this study utilizes latent profile analysis to examine the Big Five personality ...
Mingjun Wang
doaj   +1 more source

Gender differences in self-compassion: a latent profile analysis of compassionate and uncompassionate self-relating in a large adolescent sample

Current Psychology, 2022
Self-compassion, a healthy way of relating to oneself, may promote psychological resilience during adolescence. How adolescents engage with self-compassion, and whether they have distinct self-compassionate or uncompassionate psychological profiles, is ...
Madeleine Ferrari, A. Beath, Danielle A. Einstein, Keong Yap, C. Hunt   +4 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Fostering Playfulness in 2-to-6-Year-Old Children: A Longitudinal Study of Parental Play Support Profiles and Their Effects on Children’s Playfulness

Behavioral Sciences
Parental play support is crucial to children’s playfulness. Using a person-centered approach, we identified profiles of parental play support based on self-assessed roles.
Isabelle Duss, Cornelia Rüdisüli, Corina Wustmann Seiler, Patricia Lannen   +3 more
doaj   +1 more source

Personality and socio-demographic variables in teacher burnout during the COVID-19 pandemic: a latent profile analysis

Scientific Reports, 2022
Although it is well-known that teaching is one of the most stressful jobs, teacher burnout during the COVID-19 pandemic has not been thoroughly investigated. The main aims of this study were to identify distinct teacher burnout profiles and examine their
C. Răducu, Elena Stănculescu
semanticscholar   +1 more source