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Treatment of Latent Tuberculosis Infection [PDF]
Treatment of latent tuberculosis (TB) infection is an important component of TB control programs in both high- and low-prevalence countries. Clinical trials of treatment of latent TB conducted over several decades have demonstrated that preventive treatment can reduce the risk of developing active TB up to 90%.
Neil W Schluger
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Treatment of latent tuberculosis infection
Seminars in Respiratory Infections, 2003Treatment of latent tuberculosis infection (LTBI) is considered an essential component of TB control programs in several industrialized countries and is being used in selected situations in developing countries. In 2000, the American Thoracic Society (ATS) and Centers for Disease Control and Prevention (CDC) published new recommendations on the ...
DE ROSA, Francesco Giuseppe +1 more
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Seminars in Respiratory and Critical Care Medicine, 2004
Latent tuberculosis infection (LTBI) is a clinical condition characterized by a positive tuberculin skin test in the absence of clinical or radiological signs of active tuberculosis disease. It has been estimated that one third of the world's population is latently infected with Mycobacterium tuberculosis and serves as an enormous reservoir for future ...
Eric, Nuermberger +2 more
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Latent tuberculosis infection (LTBI) is a clinical condition characterized by a positive tuberculin skin test in the absence of clinical or radiological signs of active tuberculosis disease. It has been estimated that one third of the world's population is latently infected with Mycobacterium tuberculosis and serves as an enormous reservoir for future ...
Eric, Nuermberger +2 more
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Latent Mycobacterium tuberculosis Infection
New England Journal of Medicine, 2015The natural history of tuberculosis begins with the inhalation of Mycobacterium tuberculosis organisms; a period of bacterial replication and dissemination ensues, followed by immunologic containment of viable bacilli. The result of this process is asymptomatic latent tuberculosis infection, which is defined as a state of persistent bacterial viability,
Getahun, Haileyesus +3 more
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Update on the Treatment of Tuberculosis and Latent Tuberculosis Infection
JAMA, 2005Tuberculosis (TB) has emerged as a global public health epidemic. Despite decreasing numbers of cases in the United States since 1992, TB remains a serious public health problem among certain patient populations and is highly prevalent in many urban areas.
Henry M, Blumberg +2 more
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Treatment strategies for the latent tuberculosis infections
Journal of Mathematical Biology, 2023This study investigates the dynamics of tuberculosis transmission through mathematical modeling, incorporating exogenous reinfections and different treatment approaches for latent tuberculosis infections. We examine three types of treatment rates: saturated, unsaturated, and mass screening-then-treatment.
Hui Cao, Baojun Song, Yicang Zhou
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Latent Tuberculosis Infection and BCG Vaccination
Journal of Midwifery & Women's Health, 2005One third of the world's population is infected with Mycobacterium tuberculosis, and 5% to 10% of those infected will develop active disease. Identification and treatment of latent tuberculosis infection (LTBI) is an essential part of the public health strategy to control the spread of TB.
Lisa, Ross, Meredith, Goff
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Early Therapy for Latent Tuberculosis Infection.
American Journal of Epidemiology, 2001Abstract The risk of developing active tuberculosis is highest within the first 2 years of infection. Therefore, an intervention that targets persons with recent infection, such as identifying contacts of active cases, could be particularly effective as an epidemic control measure.
Elad Ziv +2 more
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Diagnostic Tests for Latent Tuberculosis Infection
Clinics in Chest Medicine, 2019Diagnosing latent tuberculosis (TB) infection (LTBI) is important globally for TB prevention. LTBI diagnosis requires a positive test for infection and negative evaluation for active disease. Current tests measure an immunologic response and include the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs), T-SPOT.TB and QuantiFERON ...
Michelle K, Haas, Robert W, Belknap
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Diagnosis of Latent Tuberculosis Infection
JAMA, 2005IN 2003, THE WORLD HEALTH ORGANIZATION REPORTED 8.8 million cases of tuberculosis (TB) worldwide, nearly half of them presenting with an infectious form of disease, and resulting in 1.7 million deaths from TB. Since TB transmission occurs before diagnosis in the index case, even when an optimal TB control program is in place, new and undiagnosed cases ...
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