Results 51 to 60 of about 3,027,820 (357)
The role of mitochondria in amyotrophic lateral sclerosis.
Neuroscience Letters, 2017 Mitochondria are unique organelles that are essential for a variety of cellular processes including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis.
Emma F. Smith, P. Shaw, K. D. De Vos
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Concurrent bi-lateral negotiation in agent systems
, 2003 Bi-lateral negotiations represent an important class of encounter in agent-based systems. To this end, this paper develops and evaluates a heuristic model that enables an agent to participate in multiple, concurrent bi-lateral encounters in competitive ...
Thuc Duong Nguyen +5 more
core +1 more source
Purification of residual glycerol recovered from biodiesel production
South African Journal of Chemical Engineering, 2019 Transesterification is the most widely used reaction in the production of biodiesel. It involves the breaking of the triglyceride structure and the exchange of alkyl groups with the hydroxide groups of the alcohol to obtain the new ester (biodiesel).
Fernando D. Pitt +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Lateral Transshipments: An Institutional Theory Perspective [PDF]
, 2013 Purpose: Are lateral transshipments an effective instrument to ensure the safe and efficient supply of blood? This paper will use the lens of institutional theory to determine how the blood supply chain can benefit from lateral transshipments and what ...
Richard Wilding +9 more
core +1 more source
State of play in amyotrophic lateral sclerosis genetics
Nature Neuroscience, 2013 Considerable progress has been made in unraveling the genetic etiology of amyotrophic lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the third most common neurodegenerative disease overall.
A. Renton, A. Chiò, B. Traynor
semanticscholar +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source