Results 161 to 170 of about 58,666 (254)

Mapping Intracellular Volume Fraction With Susceptibility Source Decomposition as a Marker for Tissue Cellularity

Journal of Magnetic Resonance Imaging, Volume 63, Issue 4, Page 1092-1105, April 2026.
ABSTRACT Background Pathophysiological changes affect tissue cell composition and density. For example, neurodegenerative disorders and brain tumors are associated with cell loss and abnormal accumulation, respectively. In these scenarios, if monitored and tracked, tissue cellularity might be used to inform clinical diagnosis and management. Purpose To
Giulia Debiasi, Oliver C. Kiersnowski, Giovanni Librizzi, Luca Roccatagliata, Renzo Manara, Mauro Costagli, Alessandra Bertoldo, Chunlei Liu   +7 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. [PDF]

Elife, 2019
Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY.   +7 more
europepmc   +1 more source

Altered Brain Tissue Volumes With Valproate Treatment for Schizophrenia

Journal of the Royal Society of New Zealand, Volume 56, Issue 2, April 2026.
Schizophrenia is a debilitating psychiatric condition that affects ≈0.5% of the global population. Some people with schizophrenia do not respond to first‐line antipsychotics and are prescribed clozapine; this is termed treatment‐resistant schizophrenia (TRS).
Thomas Cawood, Olivia K. Harrison, Meghan McIlwain, Robert R. Kydd, Bruce R. Russell   +4 more
wiley   +1 more source

Mapping brain change longitudinally: physical activity intervention reshapes structural alterations and functional connectivity in Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION Physical activity is a promising non‐pharmacological approach to support brain health. Although prior studies suggest cognitive benefits, it remains unclear how exercise alters brain structure and connectivity on the Alzheimer's disease (AD) continuum and whether such neural changes translate to functional improvements. This study
Ravi Dadsena, Ana S. Costa, Shari David, Luisa Haberl, Jörg B. Schulz, Kathrin Reetz, Alexa Haeger   +6 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Repeated Stress Escalates Aggression and Activity in Fronto‐Limbic Regions in Cntnap2−/− Mice

Genes, Brain and Behavior, Volume 25, Issue 2, April 2026.
Stress induced aggression emerges only after repeated restraint stress in Cntnap2−/− mice. Neuronal activity mapping revealed stress‐evoked activation in the lateral septum, lateral habenula, lateral hypothalamus, nucleus accumbens, and prefrontal cortex, with aggressive behavior positively correlating specifically with activity in the lateral septum ...
Caroline H. Hertweck, Chase A. Carter, Sarah S. McDaniel, Pierre Llorach, Hayleigh E. Tilton, Anish Kodali, Daniel J. Christoffel, Jessica J. Walsh   +7 more
wiley   +1 more source

Synapsin I Controls Synaptic Maturation of Long-Range Projections in the Lateral Amygdala in a Targeted Selective Fashion. [PDF]

Front Cell Neurosci, 2019
Lugarà E, De Fusco A, Lignani G, Benfenati F, Humeau Y.   +4 more
europepmc   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source

SNARE Complex-Associated Proteins in the Lateral Amygdala of Macaca mulatta Following Long-Term Ethanol Drinking. [PDF]

Alcohol Clin Exp Res, 2018
Alexander NJ, Rau AR, Jimenez VA, Daunais JB, Grant KA, McCool BA.   +5 more
europepmc   +1 more source