Results 41 to 50 of about 196,936 (306)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Performance of Round-Ended Concrete-Filled Steel Tubular Columns Under Combined Compression–Bending–Shear Loading

Buildings
This study develops and validates a finite element model for round-ended concrete-filled steel tubular (CFST) columns subjected to combined compression–bending–shear loading using ABAQUS.
Yan Peng, Junfeng Liu, Junping He, Zongfeng He, Fan Deng   +4 more
doaj   +1 more source

FEA of SFRC three ribbed wall panel / Azrul Md Din [PDF]

, 2014
This finite element study was carried out to investigate the steel fibre reinforced concrete with three (3) ribbed wall (SFRC-3RW) panel containing reinforced wire mesh (BRC) subjected to axial and eccentric loading also its load bearing response ...
Md Din, Azrul
core  

Development of a device to simulate tooth mobility [PDF]

, 2010
Objectives: The testing of new materials under simulation of oral conditions is essential in medicine. For simulation of fracture strength different simulation devices are used for test set-up.
Bieniek KW, Burstone CJ, Dornhofer R, Graf H, Kappert HF, Kurt-Jürgen Erdelt, Mante FK, Niedermeier W., Pospiech P, Richter EJ, Rosentritt M, Rosentritt M, Sander FG, Thilander B, Timea Lamper, Tinschert J, Tinschert J, Vult von Steyern P, Yamane M   +18 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Study on Bearing Capacity of the Existing Engineering Pile Group without Lateral Displacement during Dynamic Top-Down Construction

Advances in Civil Engineering, 2022
The bearing capacity of the vertical underpinning structure system is the key index in the design of top-down construction for adding a basement layer under existing buildings.
Zhen Wang, Yang Zhao, Xuelin Yang, Zhi Ding, Wenwei Zhu, Qingzhong Wang   +5 more
doaj   +1 more source

Resource–saving Reserve of Strength Characteristics of Longitudinal Beam of the Metro Wagon Truck [PDF]

, 2018
In this paper, an analysis of methods for calculating structures from allowable stresses and from limiting states is made. It is shown that when the transition from the longitudinal beam calculation to the allowable stresses to the calculation of the ...
Kuznetzov, A. (Aleksandr), Shavkun, V. (Vyacheslav), Skurikhin, V. (Vladislav)   +2 more
core   +2 more sources

Performance of perforated FRP stub beams subject to static transverse actions [PDF]

, 2020
This paper presents an experimental programme designed to investigate the failure mode and ultimate capacity of pultruded glass fibre reinforced polymer (GFRP) cellular profiles subject to transverse loading.
Gand, Alfred, Jarrouja, Slavi, Mohammed, Meer H M   +2 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Study on the Lateral Performance of Large-Scale Steel Casing-Reinforced Concrete Pile Composite Members

Buildings
In order to investigate the lateral working performance of large-scale steel casing-reinforced concrete pile composite members, this paper sets up large-scale steel casing-reinforced concrete pile composite members with different slenderness ratios λ ...
Duoyin Wang, Wei Liu, Chenxi Qin, Mingjie Jiang, Baojiang Gao   +4 more
doaj   +1 more source