Results 91 to 100 of about 84,353 (283)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The influence of rope guide sleeve clearance on the lateral oscillation of rope guided conveyance in mine hoist system caused by the aerodynamic force

The lateral oscillation behaviour of rope guided conveyances was so complicated that the rope guided hoisting system hasn’t been understood thoroughly so far.
Wu, Renyuan, Wang, Shuangli, Wang, Chengjun   +2 more
core   +1 more source

Nonlinear Dynamics of Automotive Brake-Induced Shimmy Under the Coupling Effect of the Steering Mechanism Clearance Joints

Vibration
Brake-induced steering wheel shimmy is a critical nonlinear dynamic phenomenon that severely compromises vehicle handling stability and driving safety.
Guo Li, Qingyun Ye, Xuze Wu, Muyang Wu, Wen Liu, Hang Wang   +5 more
doaj   +1 more source

Features of bicycle abreast riding and its application in bicycle facility operating evaluation and design optimization

Advances in Mechanical Engineering, 2017
This article aims to measure bicycle facility operating state based on the survey and analysis of bicycles’ abreast riding. We conducted a detailed bicycle operating investigation consisting of four exclusive bicycle paths in Nanjing, China, and ...
Xingchen Yan, Li Zhu, Jun Chen, Tao Wang, Xiaofei Ye   +4 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Study on steering wheel shimmy with clearance of kingpin

, 2013
The non-linear factors of tyre lateral force and contact-impact force of kingpin clearance are considered in this paper. They are brought in the shimmy model by the tyre magic formula and dynamic model of a two-state clearance mechanism.
Zhou, B, Sun, L, Zhang, N
core   +1 more source

Anatomical variation of middle concha and its clinical correlates: a study among patients attending North Bengal Medical College

National Journal of Clinical Anatomy, 2015
Background and aims: Lateral nasal wall of each nasal cavity provides the final common pathway of drainage of the muco-ciliary clearance of frontal, maxillary and anterior ethmoidal air cells.
Raktim Bandyopadhyay, Romy Biswas, Sharmistha Bhattacherjee, Sankar Prasad Kabiraj, Indrajit Gupta   +4 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source