Results 111 to 120 of about 84,353 (283)

Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Proteinopathy

Molecules
The cytoplasmic accumulation of TDP-43 aggregates remains a persistent pathological hallmark of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43 ...
Angelo Jamerlan, John Hulme
doaj   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

An ANN-Based System for Lateral Misalignment and Vertical Clearance Estimation of an Electric Vehicle During Dynamic Wireless Charging

, 2019
Due to decaying fossil fuel reserves, oil price fluctuation and detrimental effects on climate the use of fossil fuel has, people are getting more interested in other alternative energy sources.
Saha, Sanat Kumar
core   +2 more sources

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

Cerebrospinal fluid flow and clearance driven by lateral ventricle volume oscillations

Abstract In the human brain, substance clearance is intimately connected to the cerebrospinal fluid (CSF) and its flow. CSF extends from the lateral ventricles (LVs) to the parenchyma’s perivascular spaces. Macroscopic undulating CSF flow is present during both wakefulness and sleep and can be experimentally induced.
Viktor Neumaier, Moritz Bonhoeffer, Melissa Thalhammer, Julia Schulz, Gabriel Hoffmann, Juliana Zimmermann, Felix Brandl, Matthias Brendel, Igor Yakushev, Josef Priller, Jan Kirschke, Christine Preibisch, Benedikt Zott, Christian Sorg   +13 more
openaire   +1 more source

Performance Analysis of Abradable Coating Systems for Aircraft Gas Turbines

Advanced Engineering Materials, EarlyView.
Three CoNiCrAlY/YSZ/MgAl2O4 abradable liner configurations on a nickel‐superalloy are evaluated by thermal‐gradient cycling and incursion tests. Laser ablation of the bondcoat and/or Y2O3‐stabilized ZrO2 (YSZ) intermediate layer increases mechanical interlocking and bonding for thick topcoats.
Hanna Heyl, Daniel Emil Mack, Martin Tandler, Susanne Schrüfer, Robert Vaßen   +4 more
wiley   +1 more source

Whirl Simulation of Drill Collar and Assessment of Cumulative Fatigue Damage on Drill Collar Connection

Shiyou jixie, 2018
Most drill collar connection failures are attributed to cumulative fatigue caused by bending vibrations, in which the whirl caused by the eccentricity of the rotary drill collar is one of the most important bending vibrations.
Liu Anbing, Nan Lihua, Chang Dawei, Cheng Zhanquan   +3 more
doaj  

A Data-Driven Framework for Detecting Unsafe Ship–Bridge Passages Based on AIS Trajectories

Journal of Marine Science and Engineering
Ship–bridge collisions in cross-sea bridge waterways are rare but potentially catastrophic events, making conventional accident-based risk assessment difficult to implement effectively.
Qiyang Li, Hongzhu Zhou, Jiao Liu, Yibing Wang, Manel Grifoll, Pengjun Zheng   +5 more
doaj   +1 more source

Solid‐State Diffusion and Intermetallic Phase Formation in Roll‐Bonded Mg–Zn Composites With Kirigami‐Patterned Inlay

Advanced Engineering Materials, EarlyView.
Mg–Zn composites with a thickness of 0.21 mm were fabricated using roll bonding of a kirigami‐patterned Mg alloy inlay within a Zn matrix. Thermal activation following this process led to the formation of tailored intermetallic structures, which provided the composite with enhanced flexural strength.
Yaroslav Frolov, Oleksandr Bobukh, Christian Klose, Florian Nürnberger, Hans Jürgen Maier   +4 more
wiley   +1 more source