Results 111 to 120 of about 219,064 (327)

The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]

, 2008
Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Marri, P.R., Ochman, H., Passel, M.W.J., van   +2 more
core   +4 more sources

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

A gene horizontally transferred from bacteria protects arthropods from host plant cyanide poisoning

eLife, 2014
Cyanogenic glucosides are among the most widespread defense chemicals of plants. Upon plant tissue disruption, these glucosides are hydrolyzed to a reactive hydroxynitrile that releases toxic hydrogen cyanide (HCN). Yet many mite and lepidopteran species
Nicky Wybouw, Wannes Dermauw, Luc Tirry, Christian Stevens, Miodrag Grbić, René Feyereisen, Thomas Van Leeuwen   +6 more
doaj   +1 more source

Auxin-dependent cell cycle reactivation through transcriptional regulation of Arabidopsis E2Fa by lateral organ boundary proteins [PDF]

, 2011
Multicellular organisms depend on cell production, cell fate specification, and correct patterning to shape their adult body. In plants, auxin plays a prominent role in the timely coordination of these different cellular processes. A well-studied example
Beeckman, Tom, Berckmans, Barbara, Bogre, Laszlo, De Jaeger, Geert, De Veylder, Lieven, Friml, Jiri, Koncz, Csaba, Lessa Alvim Kamei, Claire, Maes, Sara, Magyar, Zoltan, Naramoto, Satoshi, Parizot, Boris, Persiau, Geert, Schmid, Stephan PC, Simon, R, Vassileva, Valya   +15 more
core   +2 more sources

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Modelling prokaryote gene content

Evolutionary Bioinformatics, 2006
The patchy distribution of genes across the prokaryotes may be caused by multiple gene losses or lateral transfer. Probabilistic models of gene gain and loss are needed to distinguish between these possibilities.
Edward Susko, Andrew J. Roger, Matthew Spencer   +2 more
doaj  

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen

Biology Direct, 2012
Sterols are key components of eukaryotic cellular membranes that are synthesized by multi-enzyme pathways that require molecular oxygen. Because prokaryotes fundamentally lack sterols, it is unclear how the vast diversity of bacterivorous eukaryotes that
Takishita Kiyotaka, Chikaraishi Yoshito, Leger Michelle M, Kim Eunsoo, Yabuki Akinori, Ohkouchi Naohiko, Roger Andrew J   +6 more
doaj   +1 more source

Peak‐in‐Valley Metal Nano‐Architectures via E‐Beam‐Guided Metal Oxide Redox

Advanced Functional Materials, EarlyView.
Focused electron beam irradiation of nanoelectrosprayed water‐ammonia films enables the synthesis of topologically complex metal nanostructures via solvent‐mediated metal/metal‐ion redox control. Low ammonia favors radiolytic oxidation, etching copper.
Auwais Ahmed, Andrei G. Fedorov
wiley   +1 more source

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M, Higginbottom, A, Nanou, A, Ning, K, Shaw, P, Valori, CF, Wyles, M   +6 more
core   +1 more source