Results 211 to 220 of about 2,167,307 (320)

The Oscillating Lateral Hypothalamus and the Orexinergic System

, 2018
Neurons which release the orexins (OX)/hypocretins peptides and are located in the lateral hypothalamus (LH) are key regulators of energy metabolism, arousal and sleep-wake stability, motivated behaviors. This thesis presents three data sets focused on the synaptic wiring of OX-A cell bodies in relation to state-dependent behavior in mice.
openaire   +1 more source

The Fat‐Body Secreted Neuropeptide CCHa2 Signals Insulin‐Producing Cells in the Brain to Promote Sleep

Genes, Brain and Behavior, Volume 25, Issue 6, December 2026.
A targeted screen reveals that the adipose‐derived signal from the CCHa2 neuropeptide signals the insulin‐producing cells to form a nutrient‐sensitive axis that controls sleep duration and intensity in Drosophila. ABSTRACT Sleep is a fundamental behavior regulated by diverse environmental and physiological cues.
Samaneh Biglari, Shangyu Gong, Miranda C. Wang, Ciara A. Payne, Matthew R. Kauffman, Justin R. DiAngelo, Alex Keene   +6 more
wiley   +1 more source

Hypothalamic Neurochemical and Microglial Suppression in Long‐Standing Human Hibernation‐Like Syndrome

Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.
A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Wei Jiang, Andries Kalsbeek, Roelof A. Hut, Dick F. Swaab, Chun‐Xia Yi   +4 more
wiley   +1 more source

Could the Lateral Hypothalamus Be a New Target for Therapeutic Intervention to Prevent Seizures? [PDF]

Epilepsy Curr
Goodman JH.
europepmc   +1 more source

Multi‐Organ Inflammatory and Endocrine Crosstalk Shapes the Early Brain Response to Combined Burn and Blast Injury

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Concomitant burn injury and blast‐induced mild TBI lead to a magnified neuroimmune response shaped by endocrine stress‐related pathways and IL‐1R1‐dependent inflammatory signals, which also produce cytokine‐mediated impairment of erythropoiesis. These integrated systemic and CNS responses illustrate how inflammation, hematopoietic adaptation, and early
Hana C. Schwierling, Satarupa Sengupta, John G. Noel, Christopher J. O'Connell, Andrew S. Potter, Mike Adam, Matthew J. Robson, Jason C. Gardner   +7 more
wiley   +1 more source

Electroacupuncture Pretreatment Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Engulfment by Microglia in the Lateral Hypothalamus. [PDF]

CNS Neurosci Ther
Zhou X, Yang P, Dong C, Chang H, Zhang F, Shu Q, Wei N, Zhang B, Wu Y, Shao W, Cai R, Yu Q.   +11 more
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, Volume 13, Issue 61, 3 November 2026.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Gestational High-Fat Diet Drives Premature Differentiation of Orexigenic Neurons and Reactivity of Astrocytes in the Fetal Rat Lateral Hypothalamus. [PDF]

Brain Sci
Galindo-Solano N, Trejo-Villarreal X, Díaz-Olivares G, Rea-Palomino G, Montes-Aguirre D, Villagrán-Santa-Cruz M, Gutiérrez-Ospina G.   +6 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Inhibition of the lateral hypothalamus emboldens adult female spiny mice to huddle with an established group of novel peers. [PDF]

Sci Rep
Roshko VC, Gose NA, Kelly AM.
europepmc   +1 more source