Results 41 to 50 of about 62,207 (260)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The fourth ethical comment towards COVID-19 (three years later). Trust and faith: social and moral profile of vaccination

Russian Journal of Infection and Immunity, 2023
The summarizing up the semantic and systemic results should comprise the next phase to provide insights into COVID-19 pandemic and consider it as a modern epidemic and humanitarian crisis on global level. The journal Infection and Immunity regularly and consistently present the results of ethically viewed legal framework of the pandemic and the ...
Olga I. Kubar, Galina L. Mikirtichan
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Influence of Intra-Organizational Trust on Organizational Outcomes

Operations Research and Decisions, 2018
Nowadays, trust is perceived as one of the key factors that can build an organization's competitive advantage, increase the efficiency of its functioning and ability to develop.
Agnieszka Bieńkowska, Katarzyna Walecka-Jankowska, Anna Zabłocka-Kluczka, Joanna Zimmer   +3 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Effects of Long-Lead Monitoring Requests on Driver Trust, Forward Gaze Rate, and Takeover Performance in Level 3 Automated Driving

IEEE Access
Control transitions from automated to manual driving represent one of the most safety-critical challenges in Level 3 (L3) automated driving. Although monitoring requests (MRs) have been shown to facilitate this process, prior research has predominantly ...
Sakura Akahoshi, Yuichi Saito, Makoto Itoh   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Prov-Trust: Zero-trust dynamic access control technology based on anomaly detection of provenance graph

Journal of King Saud University: Computer and Information Sciences
The core principle of Zero Trust Architecture (ZTA), “Never Trust, Always Verify”, provides strong protection against external infiltration and lateral movement.
Xingchen Li, Lifeng Cao, Jinlong Bai, Hengyi Lv, Xuehui Du   +4 more
doaj   +1 more source

Engaged Scholarship: Reflections from a Multi-Talented, National Partnership Seeking to Strengthen Capacity for Sustainability

Engaged Scholar Journal, 2015
This paper describes a national partnership of academic researchers, government representatives, and sustainability practitioners who sought to strengthen the capacity of 16 biosphere reserve organizations working across Canada to promote sustainability
Maureen G. Reed, H. Godmaire, Marc-Andre Guertin, Dominique Potvin, Paivi Abernethy   +4 more
doaj   +1 more source