Results 121 to 130 of about 2,203 (211)

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Superior Intracellular Detection of Cytokines, Transcription Factors, and Phosphoproteins by CyTOF Compared With Fluorescent Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Unraveling biological complexity, such as immune subset distribution in infectious disease(s), autoimmunity, or tumor heterogeneity, requires technologies capable of single‐cell proteomic analysis such as flow cytometry. Surface phenotyping alone is often insufficient, as interrogating functional capacity is required to determine cellular ...
Michael J. Cohen, Erika L. Smith‐Mahoney, Madison Bailey, Ling Wang, Lauren J. Tracey, Laura Polanco, David King, Christina Loh, Amedeo J. Cappione III, Anna C. Belkina, Jennifer E. Snyder‐Cappione   +10 more
wiley   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Sibling Involvement and Documentation in Pediatric Eating Disorder Care

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective When a young person has an eating disorder (ED), the entire family, including siblings, is affected. Despite recommendations in clinical guidelines and treatment manuals to involve and support siblings, little is known about how this is enacted and documented in practice.
Amalie Schumann, Elizabeth Rapa, Louise Dalton   +2 more
wiley   +1 more source

A globally consistent scaling relationship reveals stabilizing effects of dominant species in plant communities

Ecography, EarlyView.
Despite extensive research, stabilizing mechanisms in ecosystems remain uncertain. Taylor's power law (TPL) is a pervasive ecological pattern that describes how variance scales with mean abundance (σ2 = aμᵇ). While TPL has been widely studied within populations, its role across species within communities and its implications for stability remain ...
Clara Gracia, Jules Segrestin, Jan Lepš, Peter B. Adler, Susan P. Harrison, Lars Götzenberger, Enrique Valencia, Víctor Lecegui, Manuele Bazzichetto, Roberto Canullo, Stefano Chelli, Jürgen Dengler, Jiri Dolezal, David J. Eldridge, Franz Essl, Felícia M. Fischer, Anaclara Guido, Lauren Hallet, Tomas Herben, Norbert Hölzel, Anke Jentsch, Miklós Kertész, Xiaofei Li, Gábor Ónodi, Robin J. Pakeman, Alain Paquette, Kersti Pussa, Anita C. Risch, Marta Rueda, Wolfgang Schmidt, Ute Schmiedel, Zhiwei Zhong, Martin Zobel, Francesco de Bello   +33 more
wiley   +1 more source

Proceedings of the Addiction Health Services Research (AHSR) 2020: Virtual Conference: Part 2. [PDF]

Addict Sci Clin Pract, 2020
europepmc   +1 more source

Nanofiber PVA‐Based Membranes Incorporating Functionalized Spanish Broom Derivatives for Sustainable Water Purification

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study investigates Spanish broom (Spartium junceum) as a renewable source for electrospun composite membranes in sustainable water purification. MCC and biochar were functionalized with eco‐friendly precursors and nanomaterials (i.e., HNT, β‐CDs) to develop hybrid PVA nanofiber composites.
Giulia Rando, Silvia Sfameni, Jozefien Geltmeyer, Alessandra Palella, Lorenzo Spadaro, Alberto Riminucci, Karen De Clerck, Maria Rosaria Plutino   +7 more
wiley   +1 more source

Navigating the Dual Pandemics: Challenges to Faculty Diversity and Student Success

New Directions for Community Colleges, EarlyView.
Lorenzo Baber, Karla Velasco, Jeongsan Hwang, Gianina Baker   +3 more
wiley   +1 more source

Quantifying the impact of a computer‐aided diagnostic score on the clinical diagnosis of functional seizures

Epilepsia, EarlyView.
Abstract Objective The diagnosis of functional/dissociative seizures (FDS) without ictal video‐electroencephalography is challenging. The Functional/Dissociative Seizures Likelihood Score (FSLS) is a machine learning‐based diagnostic score that aims to help clinicians identify FDS.
Wesley T. Kerr, Katherine N. McFarlane, Corinne H. Allas, Samuel W. Terman, Markus Reuber, Sung Hyun Seo, Payge Barnard, Adriana Y. Koek, Amir H. Karimi, Siddhika S. Sreenivasan, Jena S. Grauer, Di Sun, Meagan Watson, Elissa H. Patterson, James Castellano, Anto I. Bagić, L. Brian Hickman, Kenneth H. Kutschman, Laurence Knowles, Alistair Wardrope, Piyush Ostwal, Bridget K. MacDonald, Melissa Berry, Lomalan Reddy, Najda Robinson‐Mayer, Nicholas J. Beimer, Rachna Reddy, Sarah K. Yaghoubi, Laura A. Kirkpatrick, Danielle R. Carns, Alex J. Israel, Jamie D. Feusner, Zongqi Xia, Yanshan Wang, Laura A. Strom, Page B. Pennell, John M. Stern, Lubomir Hadjiiski, William C. Stacey   +38 more
wiley   +1 more source