Results 101 to 110 of about 936,967 (303)

Contralateral Limberg flap reconstruction for pilonidal disease recurrence

Asian Journal of Surgery, 2019
Summary: To identify surgical techniques applied in case of recurrence in patients with pilonidal sinus, who have undergone primary treatment with Limberg flap, and to present our cases treated with Limberg flap reconstruction prepared from the ...
Barış Özcan, Özer İlkgül
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Parallel Corpus Analysis of Text and Audio Comprehension to Evaluate Readability Formula Effectiveness: Quantitative Analysis

Journal of Medical Internet Research
BackgroundHealth literacy, the ability to understand and act on health information, is critical for patient outcomes and health care system effectiveness.
Arif Ahmed, Gondy Leroy, David Kauchak, Prosanta Barai, Philip Harber, Stephen Rains   +5 more
doaj   +1 more source

A Guide to Nesting Sea Turtles in Florida

EDIS, 2021
Florida’s coastline provides critical habitat for sea turtle nesting, as it has for millions of years. Throughout the state, three of the seven species of sea turtles in the world have significant nesting populations.
Analisa Duran, Ruth Francis-Floyd, Maia Patterson Mcguire, Iskande Larkin   +3 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiota: a new perspective for bioavailability of selenium and human health

npj Science of Food
The gut microbiota can metabolise and transform selenium, and even compete with the host for it. This provides new insights into the bioavailability of selenium and the mechanisms through which it exerts its beneficial effects.
Xuehua Wang, Yan Zhong, Zhenzhou Zhu, Na Zhang, Xu Chen, Feifei Wang, Li Wang, Cheng Chen, Jiangling He, Shuyi Li   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Testimony of Allison Porter Before the Commission on the Future of Worker-Management Relations [PDF]

, 1994
Includes a sample strike notice simulation beginning on page 5.Testimony_Porter_022494.pdf: 263 downloads, before Oct.
Porter, Allison
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source