Results 81 to 90 of about 814,993 (237)

Nominee handbook for schools and PRUs, from September 2010 [PDF]

open access: yes, 2010
"This handbook is designed for nominees who will be the school representative on the inspection team during their school's inspection. The handbook has primarily been developed with the needs of school headteachers, deputy headteachers and senior ...

core  

The audience for Old English texts: Ælfric, rhetoric and ‘the edification of the simple’ [PDF]

open access: yes, 2014
There is a persistent view that Old English texts were mostly written to be read or heard by people with no knowledge of Latin, or little understanding of it, especially the laity.
Gittos, Helen
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

External information environment required for cross disciplinary thinking in large language models based on interdisciplinary lay summary writing

open access: yesScientific Reports
External information stimuli are crucial for humans to reintegrate knowledge and activate cross-disciplinary thinking. This study investigates how the external information environment affects LLMs’ cross-disciplinary thinking through analyzing generated ...
Mei Chen   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

A plain language summary of the perspectives of women who were interviewed about their experiences with uterine fibroids

open access: yesJournal of Comparative Effectiveness Research
This summary describes what researchers learned during interviews of women with uterine fibroids and heavy menstrual bleeding (or period bleeding). At this time, little is known about how women perceive the impact of uterine fibroids on their lives and ...
Elke Hunsche   +4 more
doaj   +1 more source

La pauvreté et la citoyenneté dans les suppliques du xive siècle

open access: yesL'Atelier du CRH, 2015
The petitions to Taddeo Pepoli lord of Bologna (1337-1347) represents the most important corpus of supplications addressed to lay authority in 14th century Italian state, both for number of deeds and quality.
Massimo Vallerani
doaj   +1 more source

People in Public Health. Research Summary [PDF]

open access: yes, 2011
Members of the public are becoming increasingly important in the delivery of public health programmes. The work they do varies. They might give out information about a health issue or tell people about a local service.
Rooke, S, South, J, Woodward, J
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

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