Results 91 to 100 of about 42,248,778 (304)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2019 Layer-by-layer (LBL) assembly of colloidal crystals (CCs) allows for the fine control of the thickness and architecture of the resulting crystals. Various methods have been developed for the LBL assembly of CCs of hard spheres. However, these methods are
Shuang Liang (211832) +2 more
core +1 more source
Layer‐By‐Layer Approach to Improve the Capacitance of Conducting Polymer Films
Advanced Electronic MaterialsIn the pursuit of energy storage devices offering high power density, rapid charge and discharge rates, a layer‐by‐layer deposition approach is shown to improve the capacitive properties of conducting polymer‐based devices.
Małgorzata Skorupa +6 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Advanced Materials InterfacesToday, the most effective and suitable method to obtain molecular H2 is the extraction from mixtures where it is present, using gas‐sieving membranes.
Giacomo Foli +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Layer-by-layer assembly of multilayer optical lattices: Application to displaced dice lattice
, 2020 We propose methods for synthesizing multilayer optical lattices of cold atoms in a layer-by-layer manner, to unlock the potential of optical lattices in simulating the fascinating physics of multilayer systems.
Lei Hao (5961590)
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Layer-by-Layer AB-Stacked Bilayer Graphene Growth Through an Asymmetric Oxygen Gateway
, 2019 Compared with the semimetallic single layer graphene (SLG), large-sized bilayer graphene with a desired stacking order is extremely useful in the twilight of two-dimensional electronics era.
Zhengzong Sun (2000251) +7 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source