Results 71 to 80 of about 42,248,778 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Uncovering the Galloway Viking Hoard, layer by layer

, 2017
Hold on to your Viking helmet; you’re about to dig, layer by layer, into one of the most extraordinary Viking hoards ever found on the British Isles – the Galloway Hoard – with Dr Martin Goldberg, Senior Curator at National Museums ...
Goldberg, D Martin
core  

Layer-by-Layer Assembly of Two-Dimensional Colloidal Cu₂Se Nanoplates and Their Layer-Dependent Conductivity

, 2016
Colloidal assembly is one of the highly active areas in nanoscale science and technology as it plays an important role in organizing nanoscale building blocks into hierarchical and functional systems for practical applications.
Guihua Yu (1440559), Deji Akinwande (1424785), Weinan Zhu (1640407), Yue Zhu (306128), Lele Peng (1440562)   +4 more
core   +1 more source

Decrease of Antimicrobial Resistance through Polyelectrolyte-Coated Nanoliposomes Loaded with β-Lactam Drug

Pharmaceuticals, 2018
Currently, one of the greatest health challenges worldwide is the resistance to antibiotic drugs, which has led to the pursuit of new alternatives for the recovery of biological activity, where the use of different types of nano-systems has shown an ...
Lina M. Arévalo, Cristhian J. Yarce, José Oñate-Garzón, Constain H. Salamanca   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Layer-by-Layer Self-Assembly of Organic−Organometallic Polymer Electrostatic Superlattices Using Poly(ferrocenylsilanes)

, 2016
Water-soluble poly(ferrocenylsilane) (PFS) and poly(styrenesulfonate) (PSS) of alternating charge are shown to self-assemble in a layer-by-layer fashion on primed Au, Si, and quartz substrates to create the first examples of organic−organometallic ...
K. Nicole Power-Billard (3055254), Frieder Jäkle (2443651), C. N. Catherine Lam (3055251), Josie Galloro (3055245), Ian Manners (1314384), Geoffrey A. Ozin (1411396), A. Wilhelm Neumann (1741633), Igor Sokolov (361571), Madlen Ginzburg (2984859), Sanming Yang (3055248)   +9 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The onset of instability in unsteady boundary-layer separation

, 1996
The process of unsteady two-dimensional boundary-layer separation at high Reynolds number is considered. Solutions of the unsteady non-interactive boundary-layer equations are known to develop a generic separation singularity in regions where the ...
K. W. Cassel, J. D. A. Walker, Smith, FT, Cassel, KW, Walker, JDA, F. T. Smith   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source