Results 51 to 60 of about 2,136,610 (293)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Layer-by-Layer Nano-assembly: A Powerful Tool for Optical Fiber Sensing Applications

open access: yesSensors, 2019
The ability to tune the composition of nanostructured thin films is a hot topic for the design of functional coatings with advanced properties for sensing applications.
Pedro J. Rivero   +2 more
doaj   +1 more source

Layer-by-layer assembly of organic films and their application to multichannel surface plasmon resonance sensing [PDF]

open access: yes, 2004
This thesis provides a study of a single chip, multi-channel surface plasmon resonance (SPR) imaging system. The equipment has no moving parts and uses a single sensor "chip" onto which multiple channels can be incorporated.
Palumbo, Marco, Marco Palumbo, Dott
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology

open access: yesAdvanced Engineering Materials, EarlyView.
We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham   +7 more
wiley   +1 more source

Filmes poliméricos ultrafinos produzidos pela técnica de automontagem: preparação, propriedades e aplicações

open access: yesQuímica Nova, 2001
The self-assembly technique is a powerful tool to fabricate ultrathin films from organic compounds aiming at technological applications in molecular electronics.
Paterno Leonardo Giordano   +2 more
doaj  

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

open access: yesAdvanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni   +7 more
wiley   +1 more source

Microwave-Assisted Synthesis of Reduced Graphene Oxide with Hollow Nanostructure for Application to Lithium-Ion Batteries

open access: yesNanomaterials, 2022
In this study, reduced graphene oxide (RGO) with a hollow nanostructure was successfully synthesized by layer-by-layer self-assembly using electrostatic interactions and van der Waals forces between building blocks, and its lithium storage ...
Minseop Lee, Seung-Min Paek
doaj   +1 more source

Construction of multilayer coatings for flame retardancy of ramie fabric using layer-by-layer assembly

open access: yes, 2017
Complex multilayer coatings composed of α-zirconium phosphate (ZrP), polyethylenimine (PEI), and ammonium polyphosphate (APP) were constructed via layer-by-layer assembly method for flame retardant ramie fabric.
Zhao, Li   +7 more
core   +1 more source

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