Results 111 to 120 of about 3,044,337 (312)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Applied SciencesBackground: Fluoride is vital in dentistry for caries prevention, enhancing remineralization, and inhibiting bacteria. Incorporating fluoride into restorative materials like glass-ionomer cements, compomers, and giomers has significantly increased ...
Dominik Tokarczuk +8 more
doaj +1 more source
Numerical simulation of boundary-layer control using MEMS actuation [PDF]
MEMS actuators and their effect on boundary layers is investigated using numerical simulation. The thesis is specifically focussed on jet actuators and their application to the targeted control of turbulent boundary layers.
Lockerby, Duncan A.
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Influence of higher order effects on the vortex instability of thermal boundary layer flow in a wedge shaped domain [PDF]
, 2005 We reconsider the onset of streamwise vortices in the thermal boundary layer flow induced by an inclined upward-facing heated semi-infinite surface placed within a Newtonian fluid.
Rees, DAS +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Revista Brasileira de Zootecnia, 2007 Com o objetivo de estabelecer a exigência nutricional em metionina + cistina para galinhas poedeiras leves e semipesadas no período de 34 a 50 semanas de idade, 360 poedeiras (metade Lohmann e metade Lohmann Brown) foram submetidas a uma ração basal ...
Luciano Moraes Sá +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Surface Temperature and Surface-Layer Turbulence in a Convective Boundary Layer
, 2013 Previous laboratory and atmospheric experiments have shown that turbulence influences the surface temperature in a convective boundary layer. The main objective of this study is to examine land-atmosphere coupled heat transport mechanism for different ...
Meteorol, Boundary-Layer
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