Results 121 to 130 of about 3,044,337 (312)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Growth, Structure and Prediction of the Thermal Internal Boundary Layer

open access: yes, 1988
The Thermal internal Boundary Layer (TIBL) is a dynamic and turbulent mesoscale feature of the coastal atmosphere that forms over the land during conditions of onshore flow.
Comrie, Andrew Charles
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Layers of Looking

open access: yesi-Perception, 2011
The films that I make are part documentary, part film essay, part visual poem. They are created out of a series of up to 30 drawings that are animated. The process from research to completion takes about 2 years, and at the end of it there is a film and a number of drawings that can be exhibited.
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Layer-by-Layer-Coated Cellulose Fibers Enable the Production of Porous, Flame-Retardant, and Lightweight Materials

open access: yes
New sustainable materials produced by green processing routes are required in order to meet the concepts of circular economy. The replacement of insulating materials comprising flammable synthetic polymers by bio-based materials represents a potential ...
Lorenza Maddalena (5777810)   +7 more
core   +2 more sources

Layer-by-Layer Nanoarchitectonics: A Method for Everything in Layered Structures

open access: yesMaterials
The development of functional materials and the use of nanotechnology are ongoing projects. These fields are closely linked, but there is a need to combine them more actively. Nanoarchitectonics, a concept that comes after nanotechnology, is ready to do this.
openaire   +2 more sources

Uncovering the Galloway Viking Hoard, layer by layer

open access: yes, 2017
Hold on to your Viking helmet; you’re about to dig, layer by layer, into one of the most extraordinary Viking hoards ever found on the British Isles – the Galloway Hoard – with Dr Martin Goldberg, Senior Curator at National Museums ...
Goldberg, D Martin
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Layer-by-Layer Assembly Modulated by Host–Guest Binding

open access: yes, 2019
A strategy has been devised for improving the quality of polyelectrolyte multilayers formed via the layer-by-layer technique. This strategy involves host–guest complexation of the pendant ions of a polyelectrolyte to reduce their affinity toward the ...
Nabendu B. Pramanik (6191846)   +3 more
core   +1 more source

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