Results 111 to 120 of about 4,599,256 (278)
Endodontology, 2019 Introduction: A successful root canal therapy is largely dependent on thorough chemo-mechanical debridement of the root canal space. However, mechanical preparation inadvertently forms an amorphous layer, known as the “smear layer.” Traditionally used ...
Suparna Ganguly Saha +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Effect of Uterine Closure Methods During Cesarean Section on Isthmocele Development
Cerrahpaşa Medical JournalObjective: Isthmocele is frequently encountered due to the increasing rates of cesarean deliveries nowadays. This study aims to evaluate the effectiveness of uni-layer and dual-layer uterine closure techniques in preventing isthmocele formation 6 months ...
Shamsi Mehdiyev +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Virtual and Physical PrototypingThe wire arc additive manufacturing (WAAM) process often begins printing on a substrate. In some cases, the substrate could act as a functional part of the WAAM-fabricated parts. In this work, ER70S-6 is directly deposited onto a 316L substrate using the
Wengang Zhai +3 more
doaj +1 more source
Form, synapses and orientation topography of a new cell type in layer 6 of the cat's primary visual cortex. [PDF]
Sci Rep, 2022 Srivastava M +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
State-Dependent Modulation of Activity in Distinct Layer 6 Corticothalamic Neurons in Barrel Cortex of Awake Mice. [PDF]
J Neurosci, 2022 Dash S, Autio DM, Crandall SR.
europepmc +1 more source