Results 1 to 10 of about 68,495 (293)

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

eLife, 2018
The evolutionary increase in size and complexity of the primate neocortex is thought to underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene that, based on its expression pattern in fetal human neocortex and progenitor ...
Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R Long, Milos Kostic, Barbara Langen, Wieland B Huttner   +7 more
doaj   +2 more sources

A Framework for Intelligence and Cortical Function Based on Grid Cells in the Neocortex [PDF]

Frontiers in Neural Circuits, 2019
How the neocortex works is a mystery. In this paper we propose a novel framework for understanding its function. Grid cells are neurons in the entorhinal cortex that represent the location of an animal in its environment.
Jeff Hawkins, Marcus Lewis, Mirko Klukas, Scott Purdy, Subutai Ahmad   +4 more
doaj   +2 more sources

The Ferret as a Model System for Neocortex Development and Evolution

Frontiers in Cell and Developmental Biology, 2021
The neocortex is the largest part of the cerebral cortex and a key structure involved in human behavior and cognition. Comparison of neocortex development across mammals reveals that the proliferative capacity of neural stem and progenitor cells and the ...
Nereo Kalebic
exaly   +3 more sources

Piezo2—peripheral baroreceptor channel expressed in select neurons of the mouse brain: a putative mechanism for synchronizing neural networks by transducing intracranial pressure pulses

Journal of Integrative Neuroscience, 2021
Here we use immunohistochemistry to examine the expression of Piezo2 in neurons of the mouse dorsal root ganglia and brain. Whereas Piezo2 is expressed in the large majority (≥ 90%) of dorsal root ganglia neurons, Piezo2 expression is restricted to ...
Jigong Wang, Owen P. Hamill   +1 more
doaj   +1 more source

Morphofunctional Characteristic of Edema-Swelling of the Cerebral Cortex of White Rats After Severe Traumatic Brain Injury Without the Use of L-Lysine Escinate and Against the Background of Its Use

Неотложная медицинская помощь, 2020
Aim of study The study is devoted to a morphometric assessment of the manifestations of edema-swelling of the somatosensory cortex (SSC) of the brain of white rats after severe traumatic brain injury (TBI) without using L-lysine escinate and when using ...
I. P. Koshman, S. S. Stepanov, A. Y. Shoronova, A. G. Kalinichev, V. A. Akulinin, D. B. Avdeyev, V. I. Sergeyev   +6 more
doaj   +1 more source

Transgenerational Effects of Prenatal Ethanol Exposure in Prepubescent Mice

Frontiers in Cell and Developmental Biology, 2022
Background: Fetal alcohol spectrum disorders (FASD) represent a leading cause of non-genetic neuropathologies. Recent preclinical evidence from suggests that prenatal ethanol exposure (PrEE), like other environmental exposures, may have a significant ...
Riley T. Bottom, Olga O. Kozanian, David J. Rohac, Michael A. Erickson, Kelly J. Huffman, Kelly J. Huffman   +5 more
doaj   +1 more source

Cholinergic Internal and Projection Systems of Hippocampus and Neocortex Critical for Early Spatial Memory Consolidation in Normal and Chronic Cerebral Hypoperfusion Conditions in Rats with Different Abilities to Consolidation: The Role of Cholinergic Interneurons of the Hippocampus

Biomedicines, 2022
The role of cholinergic projection systems of the neocortex and hippocampus in memory consolidation in healthy and neuropathological conditions has been subject to intensive research.
Elena I. Zakharova, Andrey T. Proshin, Mikhail Y. Monakov, Alexander M. Dudchenko   +3 more
doaj   +1 more source

Roots of the Malformations of Cortical Development in the Cell Biology of Neural Progenitor Cells

Frontiers in Neuroscience, 2022
The cerebral cortex is a structure that underlies various brain functions, including cognition and language. Mammalian cerebral cortex starts developing during the embryonic period with the neural progenitor cells generating neurons.
Chiara Ossola, Nereo Kalebic
doaj   +1 more source

Genetic manipulation of reptilian embryos: toward an understanding of cortical development and evolution

Frontiers in Neuroscience, 2015
The mammalian neocortex is a remarkable structure that is characterized by tangential surface expansion and six-layered lamination. However, how the mammalian neocortex emerged during evolution remains elusive.
Tadashi eNomura, Tadashi eNomura, Wataru eYamashita, Hitoshi eGotoh, Katsuhiko eOno   +4 more
doaj   +1 more source

Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes?

Frontiers in Cellular Neuroscience, 2020
Inhibitory neurons play a fundamental role in the normal operation of neuronal networks. Diverse types of inhibitory neurons serve vital functions in cortical networks, such as balancing excitation and taming excessive activity, organizing neuronal ...
Nicholas M. Bannon, Marina Chistiakova, Maxim Volgushev   +2 more
doaj   +1 more source