Results 31 to 40 of about 116,176 (291)

LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

eLife, 2020
Heterozygous loss of human PAFAH1B1 (coding for LIS1) results in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein motor function/localization that alters mitotic spindle orientation ...
Hyang Mi Moon, Simon Hippenmeyer, Liqun Luo, Anthony Wynshaw-Boris   +3 more
doaj   +1 more source

Dense Inhibitory Connectivity in Neocortex [PDF]

Neuron, 2011
The connectivity diagram of neocortical circuits is still unknown, and there are conflicting data as to whether cortical neurons are wired specifically or not. To investigate the basic structure of cortical microcircuits, we use a two-photon photostimulation technique that enables the systematic mapping of synaptic connections with single-cell ...
Fino, Elodie, Yuste, Rafael
openaire   +4 more sources

EZcalcium: Open-Source Toolbox for Analysis of Calcium Imaging Data

Frontiers in Neural Circuits, 2020
Fluorescence calcium imaging using a range of microscopy approaches, such as two-photon excitation or head-mounted “miniscopes,” is one of the preferred methods to record neuronal activity and glial signals in various experimental settings, including ...
Daniel A. Cantu, Daniel A. Cantu, Bo Wang, Michael W. Gongwer, Michael W. Gongwer, Cynthia X. He, Cynthia X. He, Anubhuti Goel, Anand Suresh, Nazim Kourdougli, Erica D. Arroyo, Erica D. Arroyo, William Zeiger, Carlos Portera-Cailliau, Carlos Portera-Cailliau   +14 more
doaj   +1 more source

An Adaptive Threshold in Mammalian Neocortical Evolution

, 2013
Expansion of the neocortex is a hallmark of human evolution. However, it remains an open question what adaptive mechanisms facilitated its expansion.
Huttner, Wieland B, Kalinka, Alex T., Kelava, Iva, Lewitus, Eric, Tomancak, Pavel   +4 more
core   +3 more sources

Layer 2/3 Pyramidal Neurons of the Mouse Granular Retrosplenial Cortex and Their Innervation by Cortico-Cortical Axons

Frontiers in Neural Circuits, 2020
The retrosplenial cortex forms part of the cingulate cortex and is involved in memory and navigation. It is ventral region, the granular retrosplenial cortex, or GRSC is characterized by the presence, of small pyramidal neurons with a distinctive late ...
Rita M. Robles, Eduardo Domínguez-Sala, Salvador Martínez, Salvador Martínez, Emilio Geijo-Barrientos   +4 more
doaj   +1 more source

Model of the early development of thalamo-cortical connections and area patterning via signaling molecules

, 2004
The mammalian cortex is divided into architectonic and functionally distinct areas. There is growing experimental evidence that their emergence and development is controlled by both epigenetic and genetic factors.
Ermentrout, G. B., Karbowski, Jan
core   +3 more sources

State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. [PDF]

, 2019
Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition ...
Garcia-Junco-Clemente, Pablo, Ringach, Dario L, Trachtenberg, Joshua T, Tring, Elaine   +3 more
core   +1 more source

A Canonical Laminar Neocortical Circuit Whose Bottom-Up, Horizontal, and Top-Down Pathways Control Attention, Learning, and Prediction

Frontiers in Systems Neuroscience, 2021
All perceptual and cognitive circuits in the human cerebral cortex are organized into layers. Specializations of a canonical laminar network of bottom-up, horizontal, and top-down pathways carry out multiple kinds of biological intelligence across ...
Stephen Grossberg
doaj   +1 more source

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

Neuroplasticity Meets Artificial Intelligence: A Hippocampus-Inspired Approach to the Stability–Plasticity Dilemma

Brain Sciences
The stability–plasticity dilemma remains a critical challenge in developing artificial intelligence (AI) systems capable of continuous learning. This perspective paper presents a novel approach by drawing inspiration from the mammalian hippocampus–cortex
Thorsten Rudroff, Oona Rainio, Riku Klén   +2 more
doaj   +1 more source