Results 1 to 10 of about 3,343,469 (285)
BMC Bioinformatics, 2021 Background RNA sequencing (RNA-seq) is a common and widespread biological assay, and an increasing amount of data is generated with it. In practice, there are a large number of individual steps a researcher must perform before raw RNA-seq reads yield ...
Nicholas J. Eagles +11 more
doaj +1 more source
CaPTure: Calcium PeakToolbox for analysis of in vitro calcium imaging data
BMC Neuroscience, 2022 Background Calcium imaging is a powerful technique for recording cellular activity across large populations of neurons. However, analysis methods capable of single-cell resolution in cultured neurons, especially for cultures derived from human induced ...
Madhavi Tippani +9 more
doaj +1 more source
Hypothyroxinaemia and Brain Development [PDF]
Acta Endocrinologica (Bucharest), 2016 The aim of this review is to indicate the current position on the role of thyroxine (T4) and fetal brain development with particular relevance to the human situation. Adequate maternal iodine nutrition and maternal circulating thyroxine (T4) concentrations are essential to ensure optimum T4 placental passage which in turn will ensure transport of T4 ...
Lazarus, J.H., Taylor, P.N.
openaire +2 more sources
spatialLIBD: an R/Bioconductor package to visualize spatially-resolved transcriptomics data
BMC Genomics, 2022 Background Spatially-resolved transcriptomics has now enabled the quantification of high-throughput and transcriptome-wide gene expression in intact tissue while also retaining the spatial coordinates.
Brenda Pardo +8 more
doaj +1 more source
Nature Communications, 2021 The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic ...
Kira A. Perzel Mandell +13 more
doaj +1 more source
Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
Nature Communications, 2020 Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes ...
Emily E. Burke +36 more
doaj +1 more source
BMC Neuroscience, 2023 Background Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular signals in a single biological sample.
Vijay Sadashivaiah +9 more
doaj +1 more source
Environmental Effects On Drosophila Brain Development And Learning [PDF]
, 2017 Brain development and behavior are sensitive to a variety of environmental influences including social interactions and physicochemical stressors. Sensory input in situ is a mosaic of both enrichment and stress, yet little is known about how multiple ...
Amei, Amei +3 more
core +5 more sources
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Molecular Brain, 2023 Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ deposition, tauopathy, neuroinflammation, and impaired cognition. The recent identification of associations between protein kinases and AD pathology has spurred interest in ...
Hyun-ju Lee +5 more
doaj +1 more source
From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]
, 2018 Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R. +13 more
core +1 more source