Results 31 to 40 of about 18,442,102 (269)

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Journal of Neuroinflammation, 2019
Background The FDA-approved small-molecule drug dasatinib is currently used as a treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on microglial and/or astrocytic neuroinflammatory responses and its mechanism of action have ...
Ka-Young Ryu, Hyun-ju Lee, Hanwoong Woo, Ri-Jin Kang, Kyung-Min Han, HyunHee Park, Sang Min Lee, Ju-Young Lee, Yoo Joo Jeong, Hyun-Wook Nam, Youngpyo Nam, Hyang-Sook Hoe   +11 more
doaj   +1 more source

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

Journal of Neuroinflammation, 2018
Background The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton’s tyrosine kinase (BTK), a kinase involved in B cell receptor signaling.
Hye Yeon Nam, Jin Han Nam, Gwangho Yoon, Ju-Young Lee, Youngpyo Nam, Hye-Jin Kang, Hyun-Ji Cho, Jeongyeon Kim, Hyang-Sook Hoe   +8 more
doaj   +1 more source

Memory compensation strategies in everyday life: similarities and differences between younger and older adults

Scientific Reports, 2023
Memory compensation strategies serve an important role in everyday functioning, especially in the face of cognitive decline. Research on the external memory compensation strategies employed by older adults has focused almost entirely on non-digital tools.
Madeleine J. Radnan, Riley Nicholson, Ruth Brookman, Celia B. Harris   +3 more
doaj   +1 more source

The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice

Molecular Brain, 2020
Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disease characterized by Aβ accumulation and tau hyperphosphorylation. Epidemiological evidence for a negative correlation between cancer and AD has led to the proposed use of tyrosine ...
Seong Gak Jeon, Hyun-ju Lee, HyunHee Park, Kyung-Min Han, Hyang-Sook Hoe   +4 more
doaj   +1 more source

Lateralised dynamic modulations of corticomuscular coherence associated with bimanual learning of rhythmic patterns

Scientific Reports, 2022
Human movements are spontaneously attracted to auditory rhythms, triggering an automatic activation of the motor system, a central phenomenon to music perception and production.
Olivia Morgan Lapenta, Peter E. Keller, Sylvie Nozaradan, Manuel Varlet   +3 more
doaj   +1 more source

Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state

Scientific Reports
Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent stem cells (hPSCs) can potentially model placental processes in vitro.
Ethan Tietze, Andre Rocha Barbosa, Bruno Araujo, Veronica Euclydes, Bailey Spiegelberg, Hyeon Jin Cho, Yong Kyu Lee, Yanhong Wang, Alejandra McCord, Alan Lorenzetti, Arthur Feltrin, Joyce van de Leemput, Pasquale Di Carlo, Gianluca Ursini, Kynon J. Benjamin, Helena Brentani, Joel E. Kleinman, Thomas M. Hyde, Daniel R. Weinberger, Ronald McKay, Joo Heon Shin, Tomoyo Sawada, Apua C. M. Paquola, Jennifer A. Erwin   +23 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus

Nature Communications
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schizophrenia have
Kynon J. M. Benjamin, Ria Arora, Arthur S. Feltrin, Geo Pertea, Hunter H. Giles, Joshua M. Stolz, Laura D’Ignazio, Leonardo Collado-Torres, Joo Heon Shin, William S. Ulrich, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, Apuã C. M. Paquola, Jennifer A. Erwin   +14 more
doaj   +1 more source

Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium.

Stem Cell Research, 2020
In this study, we established induced pluripotent stem (iPS) cell lines from postmortem dura-derived fibroblasts of four control individuals with low polygenic risk score for psychiatric disorders including schizophrenia and bipolar disorder.
Tomoyo Sawada, Kynon J.M. Benjamin, Anna C. Brandtjen, Ethan Tietze, Samuel J. Allen, Apuã C.M. Paquola, Joel E. Kleinman, Thomas M. Hyde, Jennifer A. Erwin   +8 more
doaj   +1 more source

Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

Journal of Neurodevelopmental Disorders, 2021
Background Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms.
Jannath Begum-Ali, Anna Kolesnik-Taylor, Isabel Quiroz, Luke Mason, Shruti Garg, Jonathan Green, Mark H. Johnson, Emily J. H. Jones, the STAARS and EDEN Teams   +8 more
doaj   +1 more source