Results 21 to 30 of about 18,442,102 (269)

Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD

open access: yesMolecular Brain, 2023
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ deposition, tauopathy, neuroinflammation, and impaired cognition. The recent identification of associations between protein kinases and AD pathology has spurred interest in ...
Hyun-ju Lee   +5 more
doaj   +1 more source

Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

open access: yesGenome Biology, 2019
Background DNA methylation (DNAm) is a critical regulator of both development and cellular identity and shows unique patterns in neurons. To better characterize maturational changes in DNAm patterns in these cells, we profile the DNAm landscape at single-
Amanda J. Price   +12 more
doaj   +1 more source

Data-driven identification of total RNA expression genes for estimation of RNA abundance in heterogeneous cell types highlighted in brain tissue

open access: yesGenome Biology, 2023
We define and identify a new class of control genes for next-generation sequencing called total RNA expression genes (TREGs), which correlate with total RNA abundance in cell types of different sizes and transcriptional activity. We provide a data-driven
Louise A. Huuki-Myers   +6 more
doaj   +1 more source

IDB Group Selected Development Contributions 2016-2019

open access: yes, 2020
This infographic shows selected IDB Group\u27s contributions to the Sustainable Development Goals (SDGs) reported through the Group\u27s Corporate Results Framework between 2016 and ...
Inter-American Development Bank
core   +1 more source

Music and the brain: disorders of musical listening [PDF]

open access: yes, 2006
The study of the brain bases for normal musical listening has advanced greatly in the last 30 years. The evidence from basic and clinical neuroscience suggests that listening to music involves many cognitive components with distinct brain substrates ...
Stewart, Lauren   +14 more
core   +1 more source

Development Effectiveness Overview (DEO) 2020

open access: yes, 2020
The Development Effectiveness Overview (DEO) is an annual report produced by the IDB Group to share the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
core   +1 more source

The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain [PDF]

open access: yes, 2012
The developing brain of Drosophila has become a useful model for studying the molecular genetic mechanisms that give rise to the complex neuronal arrays that characterize higher brains in other animals including mammals.
Reichert, H.   +8 more
core   +1 more source

Development Effectiveness Overview (DEO) 2020: Executive Summary

open access: yes, 2020
The Development Effectiveness Overview (DEO) is an annual report produced by the IDB Group to share the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
core   +1 more source

Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods

open access: yesBMC Genomics, 2019
Background RNA sequencing offers advantages over other quantification methods for microRNA (miRNA), yet numerous biases make reliable quantification challenging.
Carrie Wright   +10 more
doaj   +1 more source

Financing the Future with the IDB Group [PDF]

open access: yes, 2019
Mobilizing resources is critical to the implementation of the 2030 Agenda and multilateral development banks in particular have been called upon to crowd-in additional financing for the Sustainable Development Goals (SDGs).
Inter-American Development Bank
core   +1 more source

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