Results 1 to 10 of about 82,892 (269)
Development of the human neocortex
Journal of Anatomy, 2010 Even a casual survey of the agenda of the scientific meetings and tables of contents in the major journals reveals that current research on cortical development is heavily biased towards rodents, particularly mice. Indeed our understanding of mouse genetics and development has been immensely enhanced by the use of mice with spontaneous mutations and ...
Gavin Clowry, Zoltán Molnár
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Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells [PDF]
, 2020 BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions in the ...
Cifuentes, Manuel +12 more
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CXCR4 Regulates Interneuron Migration in the Developing Neocortex [PDF]
The Journal of Neuroscience, 2003 The chemotactic factors directing interneuron migration during cerebrocortical development are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated ...
Ralf K, Stumm +7 more
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Excitatory postsynaptic potentials in rat neocortical neurons in vitro. III. Effects of a quinoxalinedione non-NMDA receptor antagonist [PDF]
, 1990 1. Intracellular microelectrodes were used to obtain recordings from neurons in layer II/III of rat frontal cortex. A bipolar electrode positioned in layer IV of the neocortex was used to evoke postsynaptic potentials.
Hablitz, John H., Sutor, Bernd
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Renewed focus on the developing human neocortex
Journal of Anatomy, 2010 AbstractMany specifically human psychiatric and neurological conditions have developmental origins. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are specifically human. The human brain, and particularly the cerebral cortex, has some unique genetic, molecular, cellular and ...
Clowry, G, Molnár, Z, Rakic, P
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Neocortex expansion is linked to size variations in gene families with chemotaxis, cell–cell signalling and immune response functions in mammals [PDF]
Open Biology, 2016 Increased brain size is thought to have played an important role in the evolution of mammals and is a highly variable trait across lineages. Variations in brain size are closely linked to corresponding variations in the size of the neocortex, a distinct ...
Atahualpa Castillo-Morales +4 more
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Ephrin-B2 paces neuronal production in the developing neocortex [PDF]
BMC Developmental Biology, 2020 Abstract Background During mammalian cerebral cortex development, different types of projection neurons are produced in a precise temporal order and in stereotypical numbers. The mechanisms regulating timely generation of neocortex projection neurons and ensuring production in sufficient ...
Anthony Kischel +3 more
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Frontiers in Neuroanatomy, 2021 Mammals are born on a precocial–altricial continuum. Altricial species produce helpless neonates with closed distant organs incapable of locomotion, whereas precocial species give birth to well-developed young that possess sophisticated sensory and ...
Mirjam Kalusa +4 more
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Modulation of Intrinsic Circuits in Developing Neocortex [PDF]
Epilepsia, 2000 Numerous experimental studies have indicated that the developing rat brain is very susceptible to seizures. Immature rats have a low threshold for flurothyland kainic acid-induced seizures. Additionally, prolonged epileptiform activity is observed in slices of immature rat brain exposed to convulsant drugs in vitro.
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The Molecular and Genetic Mechanisms of Neocortex Development [PDF]
Clinics in Perinatology, 2009 This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morphologic changes that result in the ...
Alejandro L, Diaz, Joseph G, Gleeson
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