Results 31 to 40 of about 82,892 (269)

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity [PDF]

, 2013
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function.
A Ucar, A Ucar, AD Wingate, Andrew Macdonald, AS Nudelman, BG Frenguelli, Bruno G. Frenguelli, BW Luikart, C Deplagne, CE Monk, Colin McKenzie, D Edbauer, D Lagos, G Neves, GA Wayman, GR Wiggin, Gyorgy Hutvagner, HI Im, HK Lee, HY Cheng, I Shaked, J Darragh, J Remenyi, J. Simon C. Arthur, JA Hollander, JC Strum, JS Arthur, JS Arthur, Judit Remenyi, K Wibrand, KD Taganov, KF Hansen, LA O’Neill, M Pathania, ME Klein, Mirjam W. M. van den Bosch, MR Fabian, N Mellios, N Vo, Oleg Palygin, P Tognini, R Zaragoza, Rajen B. Mistry, S Anand, S Impey, SA Correa, ST Magill, Thomas Preiss, TJ Lambert, V Molnar, VA Beardmore, VM Ho, VN Kim, WW Anderson, Y Pankratov, YM Clovis, Yuriy Pankratov, YV Pankratov   +57 more
core   +6 more sources

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

eLife, 2018
The evolutionary increase in size and complexity of the primate neocortex is thought to underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene that, based on its expression pattern in fetal human neocortex and progenitor ...
Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R Long, Milos Kostic, Barbara Langen, Wieland B Huttner   +7 more
doaj   +1 more source

Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy [PDF]

, 1994
1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor ...
Hablitz, John H., Rucker, F., Sutor, Bernd, Ten Bruggencate, Gerrit   +3 more
core   +1 more source

Genetic Mechanisms Underlying Cortical Evolution in Mammals

Frontiers in Cell and Developmental Biology, 2021
The remarkable sensory, motor, and cognitive abilities of mammals mainly depend on the neocortex. Thus, the emergence of the six-layered neocortex in reptilian ancestors of mammals constitutes a fundamental evolutionary landmark.
Lucía Florencia Franchini
doaj   +1 more source

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

Isolation of genetically manipulated neural progenitors and immature neurons from embryonic mouse neocortex by FACS

STAR Protocols, 2021
Summary: The embryonic mammalian neocortex includes neural progenitors and neurons at various stages of differentiation. The regulatory mechanisms underlying multiple aspects of neocortical development—including cell division, neuronal fate commitment ...
Yusuke Kishi, Yukiko Gotoh
doaj   +1 more source

Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents

Frontiers in Neuroanatomy, 2018
The neocortex is the most complex part of the mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates.
Sebastian Römer, Hannah Bender, Wolfgang Knabe, Elke Zimmermann, Rudolf Rübsamen, Johannes Seeger, Simone A. Fietz   +6 more
doaj   +1 more source

Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]

, 2014
Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun, Acar, Göksemin, Demir, R., Tanriover, G.   +3 more
core   +1 more source

A multi-resource data integration approach: Identification of candidate genes regulating cell proliferation during neocortical development

Frontiers in Neuroscience, 2014
Neurons of the mammalian neocortex are produced by proliferating cells located in the ventricular zone (VZ) lining the lateral ventricles. This is a complex and sequential process, requiring precise control of cell cycle progression, fate commitment and ...
Cynthia M Vied, Florian eFreudenberg, Yuting eWang, Alexandre A.S.F. Raposo, David eFeng, Richard S. Nowakowski   +5 more
doaj   +1 more source

Cholinergic modulation of epileptiform activity in the developing rat neocortex [PDF]

, 1989
The effects of carbachol on picrotoxin-induced epileptiform activity and membrane properties of neurons in the developing rat neocortex were examined in an in vitro slice preparation.
Ben-Ari, Benardo, Bernd Sutor, Donoghue, Ferguson, Gutnick, Gähwiler, Haas, Haas, Hablitz, Hablitz, Hablitz, Halliwell, Hounsgaard, John J. Hablitz, Johnston, Kriegstein, Kriegstein, Krnjevic, Krnjevic, Lamour, Lamour, Madison, McCormick, McCormick, McLennan, Metherate, North, Pennefather, Sikes, Stone, Strejckova, Traub, Valentino, Vogt, Yamamoto   +35 more
core   +1 more source