Results 51 to 60 of about 82,892 (269)
New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]
, 2013 A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis +82 more
core +3 more sources
Recent advances in understanding neocortical development [version 1; peer review: 2 approved]
F1000Research, 2019 The neocortex is the largest part of the mammalian brain and is the seat of our higher cognitive functions. This outstanding neural structure increased massively in size and complexity during evolution in a process recapitulated today during the ...
Victor Borrell
doaj +1 more source
Excitatory GABA in Rodent Developing Neocortex In Vitro [PDF]
Journal of Neurophysiology, 2008 GABA depolarizes immature cortical neurons. However, whether GABA excites immature neocortical neurons and drives network oscillations as in other brain structures remains controversial. Excitatory actions of GABA depend on three fundamental parameters: the resting membrane potential ( Em), reversal potential of GABA ( EGABA), and threshold of action ...
Rheims, Sylvain +7 more
openaire +3 more sources
Laminar and Temporal Expression Dynamics of Coding and Noncoding RNAs in the Mouse Neocortex
Cell Reports, 2014 The hallmark of the cerebral neocortex is its organization into six layers, each containing a characteristic set of cell types and synaptic connections. The transcriptional events involved in laminar development and function still remain elusive.
Sofia Fertuzinhos +7 more
doaj +1 more source
Layer Specific Development of Neocortical Pyramidal to Fast Spiking Cells Synapses.
Frontiers in Cellular Neuroscience, 2016 All cortical neurons are engaged in inhibitory feedback loops which ensure excitation-inhibition balance and are key elements for the development of coherent network activity.
Olga eVoinova +6 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frontiers in Neuroanatomy, 2021 Neuroserpin is a serine protease inhibitor that regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin is strongly expressed during nervous system development as well as during adulthood, when it is ...
Dilara Kement +11 more
doaj +1 more source
An Adaptive Threshold in Mammalian Neocortical Evolution
, 2013 Expansion of the neocortex is a hallmark of human evolution. However, it remains an open question what adaptive mechanisms facilitated its expansion.
Huttner, Wieland B +4 more
core +3 more sources
Neuronal domains in developing neocortex: Mechanisms of coactivation
Neuron, 1995 The mammalian neocortex consists of columnar circuits, whose development may be controlled by patterns of spontaneous activity. Columnar domains of spontaneously coactive neurons were previously described using Ca2+ imaging of slices from developing rat neocortex.
Yuste, Rafael +3 more
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source