Results 61 to 70 of about 15,453,746 (203)

Role of mechanical morphogenesis in the development and evolution of the neocortex [PDF]

Physics of Life Reviews, 2018
During the short period of brain development, nature is able to build the only system we know capable of producing cognition, language, creativity, and consciousness. The neocortex – the outermost layer of the mammalian cerebrum – appears to be the biological substrate of these abilities.
Heuer, Katja, Toro, Roberto
openaire   +4 more sources

Embryonic regionalization of the neocortex

, 2001
Understanding the development of the vertebrate brain and in particular that of the neocortex, where high brain functions reside, remains one of the most difficult and exciting tasks in biology.
Dahmane, N, Ruiz Altaba, Ariel, Gitton, Y   +2 more
core   +1 more source

Financing the Future with the IDB Group [PDF]

, 2019
Mobilizing resources is critical to the implementation of the 2030 Agenda and multilateral development banks in particular have been called upon to crowd-in additional financing for the Sustainable Development Goals (SDGs).
Inter-American Development Bank
core   +1 more source

Role of Sox2 in the development of the mouse neocortex

Developmental Biology, 2006
The mammalian neocortex is established from neural stem and progenitor cells that utilize specific transcriptional and environmental factors to create functional neurons and astrocytes. Here, we examined the mechanism of Sox2 action during neocortical neurogenesis and gliogenesis.
Bani-yaghoub, Mahmud, Tremblay, Roger G., Lei, Joy X., Zhang, Dongling, Zurakowski, Bogdan, Sandhu, Jagdeep K., Smith, Brandon, Ribecco-Lutkiewicz, Maria, Kennedy, Jessica, Walker, P. Roy, Sikorska, Marianna   +10 more
openaire   +3 more sources

Embryonic and Early Fetal Development of the Human Neocortex [PDF]

The Journal of Neuroscience, 2000
Early corticogenesis was studied in human embryos and early fetuses from Carnegie stages 16 to 22 (5–8 gestational weeks) by using immunohistochemistry for Reelin (Reln), calretinin (CR), and glutamic acid decarboxylase (GAD). A first population of Reln-positive cells appears in the neocortical anlage at stage 16 and increases in number at stages 17–18.
G, Meyer, J P, Schaaps, L, Moreau, A M, Goffinet   +3 more
openaire   +2 more sources

An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics

Nature Communications, 2022
Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. Here, authors use human transcriptomics to capture transience and diversity of cells in middle and late prenatal development, including ...
Susana I. Ramos, Zarmeen M. Mussa, Elisa N. Falk, Balagopal Pai, Bruno Giotti, Kimaada Allette, Peiwen Cai, Fumiko Dekio, Robert Sebra, Kristin G. Beaumont, Alexander M. Tsankov, Nadejda M. Tsankova   +11 more
doaj   +1 more source

Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset.

, 2020
The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene ARHGAP11B in neocortical expansion, but the relevance for primate evolution has been unclear ...
Kurotaki, Y., Sasaki, E., Haffner, C., Huttner, W., Murayama, A., Heide, M., Okano, H., Shinohara, H.   +7 more
core   +1 more source

CXCR4 Regulates Interneuron Migration in the Developing Neocortex [PDF]

The Journal of Neuroscience, 2003
The chemotactic factors directing interneuron migration during cerebrocortical development are essentially unknown. Here we identify the CXC chemokine receptor 4 (CXCR4) in interneuron precursors migrating from the basal forebrain to the neocortex and demonstrate that stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant for isolated ...
Ralf K, Stumm, Chun, Zhou, Toshiaki, Ara, Françoise, Lazarini, Monique, Dubois-Dalcq, Takashi, Nagasawa, Volker, Höllt, Stefan, Schulz   +7 more
openaire   +2 more sources

Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome

Frontiers in Neuroanatomy, 2021
Neuroserpin is a serine protease inhibitor that regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin is strongly expressed during nervous system development as well as during adulthood, when it is ...
Dilara Kement, Rebecca Reumann, Katrin Schostak, Hannah Voß, Sara Douceau, Matthias Dottermusch, Michaela Schweizer, Hartmut Schlüter, Denis Vivien, Denis Vivien, Markus Glatzel, Giovanna Galliciotti   +11 more
doaj   +1 more source

Development of Layer 1 Neurons in the Mouse Neocortex [PDF]

Cerebral Cortex, 2014
Layer 1 of the neocortex harbors a unique group of neurons that play crucial roles in synaptic integration and information processing. Although extensive studies have characterized the properties of layer 1 neurons in the mature neocortex, it remains unclear how these neurons progressively acquire their distinct morphological, neurochemical, and ...
Jian, Ma, Xing-Hua, Yao, Yinghui, Fu, Yong-Chun, Yu   +3 more
openaire   +2 more sources