Results 71 to 80 of about 82,892 (269)
The role of adherens junctions in the developing neocortex [PDF]
Cell Adhesion & Migration, 2015 The disproportional enlargement of the neocortex through evolution has been instrumental in the success of vertebrates, in particular mammals. The neocortex is a multilayered sheet of neurons generated from a simple proliferative neuroepithelium through a myriad of mechanisms with substantial evolutionary conservation.
Adam M, Stocker, Anjen, Chenn
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex. [PDF]
PLoS ONE, 2014 Neural precursor cells (NPCs) in the neocortex exhibit a high proliferation capacity during early embryonic development and give rise to cortical projection neurons after maturation.
Ryohei Minamide +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Implantable optoelectrical devices are an effective resource for the modulation and monitoring of neural activity with high spatiotemporal resolution. This review discusses current challenges faced by these devices and outlines future perspectives for the development of next‐generation neural interfaces targeting chronic, multisite, and multimodal ...
Stella Aslanoglou +4 more
wiley +1 more source
Frontiers in Genetics, 2014 A mechanistic understanding of the pathophysiology underpinning psychiatric disorders is essential for the development of targeted molecular therapies.
Steven eColvin, Kenneth Yu-Chung Kwan
doaj +1 more source
The enhancer landscape during early neocortical development reveals patterns of dense regulation and co-option. [PDF]
PLoS Genetics, 2013 Genetic studies have identified a core set of transcription factors and target genes that control the development of the neocortex, the region of the human brain responsible for higher cognition. The specific regulatory interactions between these factors,
Aaron M Wenger +7 more
doaj +1 more source
The involvement of Rcc2 in mammalian neurogenesis [PDF]
, 2016 Rcc2 is a Rac guanine nucleotide exchange factor recently identified as a principal signaling component of integrin adhesion complexes that also plays a central role in the completion of mitosis and cytokinesis.
Yanushefski, Lisa
core +1 more source
Development of Layer 1 Neurons in the Mouse Neocortex [PDF]
Cerebral Cortex, 2014 Layer 1 of the neocortex harbors a unique group of neurons that play crucial roles in synaptic integration and information processing. Although extensive studies have characterized the properties of layer 1 neurons in the mature neocortex, it remains unclear how these neurons progressively acquire their distinct morphological, neurochemical, and ...
Jian, Ma +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Embryonic and Early Fetal Development of the Human Neocortex [PDF]
The Journal of Neuroscience, 2000 Early corticogenesis was studied in human embryos and early fetuses from Carnegie stages 16 to 22 (5–8 gestational weeks) by using immunohistochemistry for Reelin (Reln), calretinin (CR), and glutamic acid decarboxylase (GAD). A first population of Reln-positive cells appears in the neocortical anlage at stage 16 and increases in number at stages 17–18.
G, Meyer +3 more
openaire +2 more sources