Results 21 to 30 of about 82,892 (269)
Cajal–Retzius cells and the development of the neocortex
Trends in Neurosciences, 1998 The dual origin, structural organization, and evolving ascending stratification of the mammalian neocortex are explored from a developmental perspective. Layer I and subplate (layer VII) zone of the neocortex evolve first from a primordial plexiform neuropil that is established throughout the non-olfactory telencephalon and that is common to amphibians,
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Human-Specific Genes, Cortical Progenitor Cells, and Microcephaly
Cells, 2021 Over the past few years, human-specific genes have received increasing attention as potential major contributors responsible for the 3-fold difference in brain size between human and chimpanzee.
Michael Heide, Wieland B. Huttner
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Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. [PDF]
Proc Natl Acad Sci U S A, 2015 Camp JG +14 more
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Cortical Organoids to Model Microcephaly
Cells, 2022 How the brain develops and achieves its final size is a fascinating issue that questions cortical evolution across species and man’s place in the animal kingdom.
Sarah Farcy +4 more
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The SVZ stem cell niche–components, functions, and in vitro modelling
Frontiers in Cell and Developmental Biology, 2023 Neocortical development depends on the intrinsic ability of neural stem and progenitor cells to proliferate and differentiate to generate the different kinds of neurons in the adult brain.
Nesil Eşiyok, Michael Heide
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STDP in the developing sensory neocortex [PDF]
Frontiers in Synaptic Neuroscience, 2010 Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental ...
Rylan S Larsen +9 more
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Interneurons in the developing human neocortex [PDF]
Developmental Neurobiology, 2010 AbstractCortical interneurons play a crucial role in the functioning of cortical microcircuitry as they provide inhibitory input to projection (pyramidal) neurons. Despite their involvement in various neurological and psychiatric disorders, our knowledge about their development in human cerebral cortex is still incomplete.
Nada, Zecevic +2 more
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Neocortex neurogenesis and maturation in the African greater cane rat
Neural Development, 2023 Background Neocortex development has been extensively studied in altricial rodents such as mouse and rat. Identification of alternative animal models along the “altricial-precocial” spectrum in order to better model and understand neocortex development ...
Oluwaseun Mustapha +3 more
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Progenitor cell diversity in the developing mouse neocortex [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance How projection neuron types are temporally and sequentially generated in the mammalian neocortex remains unclear. We performed single-cell RNA sequencing analysis of embryonic day (E) 10.5 through E18.5 mouse neocortical cells and identified progenitor cell types across development.
Xiangbin Ruan +5 more
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Temporal transcriptomic dynamics in developing macaque neocortex
eLife, 2023 Abstract Despite intense research on mice, the transcriptional regulation of neocortical neurogenesis remains limited in humans and non-human primates. Cortical development in rhesus macaque is known to recapitulate multiple facets of cortical development in humans, including the complex composition of neural stem cells and the thicker ...
Yuan Zhao +10 more
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