Results 21 to 30 of about 15,453,746 (203)

Selective enrichment of TCF4 in GABAergic neurons during postnatal primate development [PDF]

Frontiers in Neuroanatomy
The transcription factor 4 (TCF4) gene is essential for brain development, and its disruption causes Pitt-Hopkins syndrome. Common genetic variants in TCF4 also confer risk for schizophrenia and related psychiatric disorders.
Alain C. Burette, Alain C. Burette, Rebecca I. Hipp, Rebecca I. Hipp, Sarah Salvador, Sarah Salvador, Chavely Gonzalez Ramirez, Chavely Gonzalez Ramirez, Ridthi K. R. Patel, Ridthi K. R. Patel, Naomi R. Salvador, Naomi R. Salvador, Katherine A. Dasher, Katherine A. Dasher, Jeff Bennett, Jeff Bennett, David G. Amaral, David G. Amaral, Benjamin D. Philpot, Benjamin D. Philpot, Benjamin D. Philpot   +20 more
doaj   +2 more sources

Human-Specific Genes, Cortical Progenitor Cells, and Microcephaly

Cells, 2021
Over the past few years, human-specific genes have received increasing attention as potential major contributors responsible for the 3-fold difference in brain size between human and chimpanzee.
Michael Heide, Wieland B. Huttner
doaj   +1 more source

Cortical Organoids to Model Microcephaly

Cells, 2022
How the brain develops and achieves its final size is a fascinating issue that questions cortical evolution across species and man’s place in the animal kingdom.
Sarah Farcy, Alexandra Albert, Pierre Gressens, Alexandre D. Baffet, Vincent El Ghouzzi   +4 more
doaj   +1 more source

The SVZ stem cell niche–components, functions, and in vitro modelling

Frontiers in Cell and Developmental Biology, 2023
Neocortical development depends on the intrinsic ability of neural stem and progenitor cells to proliferate and differentiate to generate the different kinds of neurons in the adult brain.
Nesil Eşiyok, Michael Heide
doaj   +1 more source

STDP in the developing sensory neocortex [PDF]

Frontiers in Synaptic Neuroscience, 2010
Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental ...
Rylan S Larsen, Deepti Rao, Paul B Manis, Paul B Manis, Paul B Manis, Paul B Manis, Benjamin D Philpot, Benjamin D Philpot, Benjamin D Philpot, Benjamin D Philpot   +9 more
openaire   +3 more sources

Development and Evolution of the Human Neocortex [PDF]

Cell, 2011
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium ...
Lui, Jan H., Hansen, David V., Kriegstein, Arnold R.   +2 more
openaire   +2 more sources

Spread of epileptiform activity in the immature rat neocortex studied with voltage-sensitive dyes and laser scanning microscopy [PDF]

, 1994
1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor ...
J. J. Hablitz, F. Rucker, Rucker, F., Ten Bruggencate, Gerrit, G. ten Bruggencate, Sutor, Bernd, Hablitz, John H., B. Sutor   +7 more
core   +2 more sources

Neocortex neurogenesis and maturation in the African greater cane rat

Neural Development, 2023
Background Neocortex development has been extensively studied in altricial rodents such as mouse and rat. Identification of alternative animal models along the “altricial-precocial” spectrum in order to better model and understand neocortex development ...
Oluwaseun Mustapha, Thomas Grochow, James Olopade, Simone A. Fietz   +3 more
doaj   +1 more source

Interneurons in the developing human neocortex [PDF]

Developmental Neurobiology, 2010
AbstractCortical interneurons play a crucial role in the functioning of cortical microcircuitry as they provide inhibitory input to projection (pyramidal) neurons. Despite their involvement in various neurological and psychiatric disorders, our knowledge about their development in human cerebral cortex is still incomplete.
Nada, Zecevic, Frances, Hu, Igor, Jakovcevski   +2 more
openaire   +2 more sources

Inter-American Development Bank Group Climate Change Action Plan 2021-2025 [PDF]

, 2021
The Climate Change Action Plan describes the IDB Groups progress since 2016 to support the regions need for low-carbon and climate-resilient development finance and its plan to raise climate ambition continuously in the region.
Inter-American Development Bank
core   +1 more source