Primary Cilia and Centrosomes in Neocortex Development [PDF]
Frontiers in Neuroscience, 2021 During mammalian brain development, neural stem and progenitor cells generate the neurons for the six-layered neocortex. The proliferative capacity of the different types of progenitor cells within the germinal zones of the developing neocortex is a ...
Michaela Wilsch-Bräuninger +1 more
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The Ferret as a Model System for Neocortex Development and Evolution [PDF]
Frontiers in Cell and Developmental Biology, 2021 The neocortex is the largest part of the cerebral cortex and a key structure involved in human behavior and cognition. Comparison of neocortex development across mammals reveals that the proliferative capacity of neural stem and progenitor cells and the ...
Carlotta Gilardi, Nereo Kalebic
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The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development [PDF]
Frontiers in Cellular Neuroscience, 2022 Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human neocortex is not yet fully understood.
Katherine R. Long +2 more
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Neurotransmitters as Modulators of Neural Progenitor Cell Proliferation During Mammalian Neocortex Development [PDF]
Frontiers in Cell and Developmental Biology, 2020 Neural progenitor cells (NPCs) play a central role during the development and evolution of the mammalian neocortex. Precise temporal and spatial control of NPC proliferation by a concert of cell-intrinsic and cell-extrinsic factors is essential for the ...
Lei Xing, Wieland B. Huttner
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Genetic manipulation of reptilian embryos: toward an understanding of cortical development and evolution [PDF]
Frontiers in Neuroscience, 2015 The mammalian neocortex is a remarkable structure that is characterized by tangential surface expansion and six-layered lamination. However, how the mammalian neocortex emerged during evolution remains elusive.
Tadashi eNomura +4 more
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What Are the Human-Specific Aspects of Neocortex Development? [PDF]
Frontiers in Neuroscience, 2022 When considering what makes us human, the development of the neocortex, the seat of our higher cognitive abilities, is of central importance. Throughout this complex developmental process, neocortical stem and progenitor cells (NSPCs) exert a priming ...
Felipe Mora-Bermúdez +1 more
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How neural stem cells contribute to neocortex development. [PDF]
Biochem Soc Trans, 2021 The mammalian neocortex is the seat of higher cognitive functions, such as thinking and language in human. A hallmark of the neocortex are the cortical neurons, which are generated from divisions of neural progenitor cells (NPCs) during development, and which constitute a key feature of the well-organized layered structure of the neocortex.
Xing L +2 more
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Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution [PDF]
Frontiers in Cell and Developmental Biology, 2022 During development, the decision of stem and progenitor cells to switch from proliferation to differentiation is of critical importance for the overall size of an organ. Too early a switch will deplete the stem/progenitor cell pool, and too late a switch
Samir Vaid, Wieland B. Huttner
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Development and Evolution of the Human Neocortex [PDF]
Cell, 2011 The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium ...
Lui, Jan H. +2 more
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Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development [PDF]
Nature CommunicationsMetabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B.
Lei Xing +12 more
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