An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex
The neocortex performs a wide range of functions, including working memory, sensory perception, and motor planning. Despite this diversity in function, evidence suggests that the neocortex is made up of repeating subunits (“macrocolumns”), each of which ...
Max Bennett
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Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy. [PDF]
BackgroundMultiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells,
Adame, Anthony +12 more
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The ability to adapt to new situations involves behavioral changes expressed either from an innate repertoire, or by acquiring experience through memory consolidation mechanisms, by far a much richer and flexible source of adaptation.
Jorge Alberto Quillfeldt +2 more
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Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex
The cerebral cortex is composed of billions of neurons that can grossly be subdivided into two broad classes: inhibitory GABAergic interneurons and excitatory glutamatergic neurons.
Elif Kon, Alexia Cossard, Yves Jossin
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The Ferret as a Model System for Neocortex Development and Evolution
The neocortex is the largest part of the cerebral cortex and a key structure involved in human behavior and cognition. Comparison of neocortex development across mammals reveals that the proliferative capacity of neural stem and progenitor cells and the ...
Carlotta Gilardi, Nereo Kalebic
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Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]
Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun +3 more
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Theta rhythm in many brain structures characterizes wakefulness and desynchronized sleep in most subprimate mammalian brains. In close relation to behaviors, theta frequency and voltage undergo a fine modulation which may involve mobilization of dorsal ...
E.T. Fonoff +3 more
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Statistical mechanics of neocortical interactions: High resolution path-integral calculation of short-term memory [PDF]
We present high-resolution path-integral calculations of a previously developed model of short-term memory in neocortex. These calculations, made possible with supercomputer resources, supplant similar calculations made in L. Ingber, Phys. Rev.
Ingber, Lester, Nunez, Paul
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The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model [PDF]
Understanding the response of the brain to haemorrhagic damage is important in haemorrhagic stroke and increasingly in the understanding the cerebral degeneration and dementia that follow head trauma and head-impact sports.
Johnstone, Daniel M. +4 more
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Ubiquitous Neocortical Decoding of Tactile Input Patterns
Whereas functional localization historically has been a key concept in neuroscience, direct neuronal recordings show that input of a particular modality can be recorded well outside its primary receiving areas in the neocortex. Here, we wanted to explore
Jonas M. D. Enander +5 more
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