Results 41 to 50 of about 134,743 (297)

Study on deformation of layered rock tunnel based on material point method [PDF]

Archives of Civil Engineering
The stability problems of layered rock mass are frequently encountered in tunnel and underground engineering. Affected by bedding plane, the mechanical properties of surrounding rock show obvious anisotropy, which makes its failure characteristics more ...
Jingjie Pang, Zhenhua Xing, Yang Li, Binwei Xia, Gexin Wan, Shusen Wang, Kang Fu   +6 more
doaj   +1 more source

The direct boundary element method: 2D site effects assessment on laterally varying layered media (methodology) [PDF]

, 2004
The Direct Boundary Element Method (DBEM) is presented to solve the elastodynamic field equations in 2D, and a complete comprehensive implementation is given. The DBEM is a useful approach to obtain reliable numerical estimates of site effects on seismic
Aki, Brebbia, Chávez-Garcı́a, Domı́nguez, Enrique Alarcón, Francisco J. Sánchez-Sesma, Geli, Jongmans, Juan José Benito, Kawase, Kim, Luco, Luzón, Makra, Marrara, Ortiz-Alemán, Papageorgiou, Parı́s, Pedersen, Raptakis, Reinoso, Sonia Álvarez-Rubio, Sánchez-Sesma, Sánchez-Sesma, Sánchez-Sesma, Sánchez-Sesma, Tadeu, Wong, Zhang   +28 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effect of layering characteristics on compressive mechanical properties and damage mechanisms of rocks: Experiments and models.

PLoS ONE
The investigation of layered rock mechanical properties is important for rock stability analysis. To examine the effects of layer inclination angle (LIA) and layer thickness (LT) on the compressive mechanical properties and damage mechanism of layered ...
Chong Chen, Aixiang Wu, Shaoyong Wang, Wutian Gong, Wei Sun, Tong Gao   +5 more
doaj   +1 more source

Fracture and Damage of Slit Charge Blasting in the Layered Rock Mass

Applied Sciences
Directional fracture blasting technology of the slit charge has broad application prospects in the drilling and blasting construction of the layered rock mass.
Chenxi Ding, Hong Su, Haitao Yang, Chenglong Xiao   +3 more
doaj   +1 more source

Blastability Classification of Fractured Rock Mass Based on Weighted Clustering Analysis

Chemical Engineering Transactions, 2017
This paper classifies the blastability of fractured rock mass based on the solid coefficient, rock impedance, unit explosive consumption and mean fracture spacing. Specifically, an evaluation model was established according to the principle of clustering
Tiejun Tao, Ping Huang, Jianmin Zhou, Hongbing Yu, Jie Li   +4 more
doaj   +1 more source

Buoyancy-driven dispersion in a layered porous rock [PDF]

Journal of Fluid Mechanics, 2015
AbstractWe investigate the longitudinal dispersion of a passive tracer by a gravity-driven flow in a porous medium consisting of a series of independent horizontal layers connected to a constant pressure source. We show that in a formation of given vertical extent, the total flux is only weakly dependent on the number of layers, and is very similar to ...
Farcas, Adrian, Woods, Andrew W
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Experimental Study on Deformation Law of Rectangular Roadway in Horizontal Layered Rock Mass

Advances in Materials Science and Engineering, 2022
In order to analyze the characteristics and mechanism of roadway deformation caused by high stress in horizontal strata, a physical model with rectangular roadway was designed.
Dinggui Hou, Yunying Zhou, Jingxiang Wang   +2 more
doaj   +1 more source