Results 51 to 60 of about 346,399 (224)

Dynamic and Regulated Association of Caveolin with Lipid Bodies: Modulation of Lipid Body Motility and Function by a Dominant Negative Mutant [PDF]

, 2003
Caveolins are a crucial component of caveolae but have also been localized to the Golgi complex, and, under some experimental conditions, to lipid bodies (LBs). The physiological relevance and dynamics of LB association remain unclear.
Carozzi, Amanda, Enrich Bastús, Carles, Ferguson, Charles, Fernandez, Manuel A., Luetterforst, Robert, Martin, Sally, Parton, Robert G., Pol i Sorolla, Albert   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Current Trends and Challenges in Location-Based Services

ISPRS International Journal of Geo-Information, 2018
Location-based services (LBS) are a growing area of research. This editorial paper introduces the key research areas within the scientific field of LBS, which consist of positioning, modelling, communication, applications, evaluation, analysis of LBS ...
Haosheng Huang, Georg Gartner
doaj   +1 more source

The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography. [PDF]

PLoS ONE, 2013
Lipid bodies (LBs), also known as lipid droplets, are complex organelles of all eukaryotic cells linked to a variety of biological functions as well as to the development of human diseases.
Rossana C N Melo, Guillherme F Paganoti, Ann M Dvorak, Peter F Weller   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism. [PDF]

PLoS ONE, 2016
Most eukaryotic cells contain varying amounts of cytosolic lipidic inclusions termed lipid bodies (LBs) or lipid droplets (LDs). In mammalian cells, such as macrophages, these lipid-rich organelles are formed in response to host-pathogen interaction ...
Daniel A M Toledo, Natália R Roque, Lívia Teixeira, Erix A Milán-Garcés, Alan B Carneiro, Mariana R Almeida, Gustavo F S Andrade, Jefferson S Martins, Roberto R Pinho, Célio G Freire-de-Lima, Patrícia T Bozza, Heloisa D'Avila, Rossana C N Melo   +12 more
doaj   +1 more source

Collaborative Search Model for Lost-Link Borrowers Information Based on Multi-Agent Q-Learning

Axioms, 2023
To reduce the economic losses caused by debt evasion amongst lost-link borrowers (LBs) and improve the efficiency of finding information on LBs, this paper focuses on the cross-platform information collaborative search optimization problem for LBs. Given
Ge You, Hao Guo, Abd Alwahed Dagestani, Ibrahim Alnafrah   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Reconstructing ecofeminism: A study of Kamala Markandaya’s nectar in a sieve

Cogent Social Sciences, 2016
The critical discourse on ecofeminism makes a novel attempt in understanding the relationship between literary texts and the problems with regard to gender and ecological crisis through various literary genres. In this context, the present paper attempts
Patil Sangita Sharnappa
doaj   +1 more source