Results 1 to 10 of about 376,115 (245)

LC-MS and CE-MS Strategies in Impurity Profiling

CHIMIA, 1999
LC-MS has become an important tool in all areas of drug discovery and development within pharmaceutical industry. It is very suitable when searching for impurities in drugs, such as reaction byproducts or degradation products. Various strategies
Wilfried M.A. Niessen
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Protein mass spectrometry extends temporal blood meal detection over polymerase chain reaction in mouse-fed Chagas disease vectors

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Chagas disease is highly prevalent in Latin America, and vector control is the most effective control strategy to date. We have previously shown that liquid chromatography tandem mass spectrometry (LC-MS/MS) is a valuable tool for identifying
Judith I Keller, Justin O Schmidt, Anna M Schmoker, Bryan A Ballif, Lori Stevens   +4 more
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TidyMass an object-oriented reproducible analysis framework for LC–MS data

Nature Communications, 2022
Reproducibility, traceability, and transparency have been long-standing issues in metabolomics data analysis. Here, the authors present tidyMass, an R-based computational framework that allows designing traceable, shareable, and reproducible data ...
Xiaotao Shen, Hong Yan, Chuchu Wang, Peng Gao, Caroline H. Johnson, Michael P. Snyder   +5 more
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LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol

Journal of Pharmaceutical Analysis, 2018
The aim of the present investigation was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC–MS) to separate, identify and characterize very small quantities of degradation products (DPs)
Uday Rakibe, Ravi Tiwari, Anand Mahajan, Vipul Rane, Pravin Wakte   +4 more
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Inferring serum proteolytic activity from LC-MS/MS data

BMC Bioinformatics, 2012
Background In this paper we deal with modeling serum proteolysis process from tandem mass spectrometry data. The parameters of peptide degradation process inferred from LC-MS/MS data correspond directly to the activity of specific enzymes present in the ...
Dittwald Piotr, Ostrowski Jerzy, Karczmarski Jakub, Gambin Anna   +3 more
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Screening Non-colored Phenolics in Red Wines using Liquid Chromatography/Ultraviolet and Mass Spectrometry/Mass Spectrometry Libraries

Molecules, 2007
Liquid chromatography/ultraviolet (LC/UV) and mass spectrometry/mass spectrometry (MS/MS) libraries containing 39 phenolic compounds were established by coupling a LC and an ion trap MS with an electrospray ionization (ESI) source, operated in negative ...
Jianping Sun, Feng Liang, Yan Bin, Ping Li, Changqing Duan   +4 more
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Comparative analysis of salivary cortisol measurements using different assay methods in relation to serum-free cortisol measurement

Practical Laboratory Medicine
Objectives: Salivary cortisol reflects the biologically active form of serum cortisol, offering a noninvasive evaluation method for the diurnal rhythm of the hypothalamic-pituitary-adrenal (HPA) axis. While liquid chromatography-tandem mass spectrometry (
Anna Lee, Sooah Jang, Sanghoo Lee, Hyun-Kyung Park, In-Young Kim, Ryunsup Ahn, Jeong-Ho Seok, Kyoung-Ryul Lee   +7 more
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A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

Pharmaceutics, 2018
In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC ...
Andrea Li-Ann Wong, Xiaoqiang Xiang, Pei Shi Ong, Ee Qin Ying Mitchell, Nicholas Syn, Ian Wee, Alan Prem Kumar, Wei Peng Yong, Gautam Sethi, Boon Cher Goh, Paul Chi-Lui Ho, Lingzhi Wang   +11 more
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ESTABILIDAD DE ALMACENAMIENTO DE ENSILADOS BIOLÓGICOS A PARTIR DE RESIDUOS DE PESCADO INOCULADOS CON BACTERIAS ÁCIDO -LÁCTICAS

Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 2009
Se elaboraron cuatro muestras por triplicado de ensilados biológicos para alimentación animal a partir de residuos de pescado, utilizando melaza como fuente de carbohidratos para el crecimiento de cuatro cepas de bacterias ácido-lácticas (BAL) aisladas ...
MS Holguín, LA Caicedo, LC Veloza
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LC/MS Analysis of Tetrodotoxin and Its Deoxy Analogs in the Marine Puffer Fish Fugu niphobles from the Southern Coast of Korea, and in the Brackishwater Puffer Fishes Tetraodon nigroviridis and Tetraodon biocellatus from Southeast Asia

Marine Drugs, 2010
Tetrodotoxin (TTX) and its deoxy analogs, 5-deoxyTTX, 11-deoxyTTX, 6,11-dideoxyTTX, and 5,6,11-trideoxyTTX, were quantified in the tissues of three female and three male specimens of the marine puffer fish, Fugu niphobles, from the southern coast of ...
Jun-Ho Jang, Jong-Soo Lee, Mari Yotsu-Yamashita   +2 more
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